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与中国人口中MASLD相关的代谢和肝脏生物标志物

Hua Chen^1,2, Zexu Chen^1,3, Xinyan Bai¹

¹Xiamen Key Laboratory for TCM Dampness Disease, Neurology & Immunology Research, Department of Traditional Chinese Medicine, Xiang'an Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, People's Republic of China.

Scientific reports

|August 27, 2025

概括

与代谢功能障碍相关的脂肪酸性肝病 (MASLD) 影响了超过三分之一的中国成年人,观察到明显的代谢和肝脏生物标志物差异. 这些指标的早期监测对于识别有风险的个人至关重要.

科学领域:

肝病学
代谢疾病
公共卫生

背景情况:

与代谢功能障碍相关的脂肪酸性肝病 (MASLD) 是一个日益严重的全球健康问题,具有重大经济影响.
患病率和相关的代谢风险因素需要进一步研究,特别是在多种人群中.

研究的目的:

在大型中国队列中分析与MASLD相关的血清生物标志物.
确定与MASLD相关的关键指标和人口群体之间的流行情况.

主要方法:

对162,699名中国人的血清指标 (ALT,AST,De-Ritis比,FBG,脂质概况,血压) 的分析.
按性别,年龄和体重进行分层,以比较MASLD和正常组.
统计分析以确定重要的生物标志物差异.

主要成果:

整体MASLD患病率为36. 57% (男性为23. 96%,女性为12. 61%).
在所有组中,ALT,De-Ritis比率,甘油三和HDL-C均有显著差异.
在大多数小组中,AST,FBG,血压,TC和LDL- C也显示出显著的变化.

结论:

特定的代谢和肝脏生物标志物与MASLD密切相关.
加强对这些指标的监测可以帮助在中国人口中早期发现MASLD风险.
建议基于生物标志物查的及时干预措施来管理MASLD.

关键词:

氨酸转移酶酸氨基转化酶禁食血液中的葡萄糖与代谢功能障碍相关的脂肪性肝病部分卫生

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