俄罗斯的酒精消费与动脉样硬化之间的关联
Nikita A Mitkin1,2, Andrew N Ryabikov3,4, Olga A Mirolyubova5
1Department of Community Medicine, UiT The Arctic University of Norway, N- 9037, Tromsø, Norway. nikita.a.mitkin@uit.no.
Scientific reports
|August 27, 2025
概括
严重的酒精消耗直接影响动脉壁,增加动脉样硬化. 危险饮酒与通过高血压导致动脉样硬化有关,而适度饮酒或不饮酒则有不同的关联.
科学领域:
- 心血管医学
- 公共卫生
- 关于成的研究
背景情况:
- 酒精消费与动脉样硬化之间存在争议.
- 了解这些关联对于心血管健康至关重要.
- 之前的研究结果是相互矛盾的.
研究的目的:
- 调查不同程度的酒精消费与动脉样硬化的标志物之间的关系.
- 区分酒精的直接影响与代谢条件介导的间接影响.
主要方法:
- 在俄罗斯阿尔汉格尔斯克对2357名普通患者和272名毒理学患者进行的横截面研究.
- 通过内膜厚度 (CIMT),斑块得分和狭窄度 (≥50%) 评估的动脉样硬化.
- 经过调整以社会人口统计学和代谢障碍因素 (肥胖,血脂障碍,高血压,糖尿病,炎症) 的量化,线性和后勤回归.
主要成果:
- 与无问题饮酒者相比,药物代谢患者的CIMT,斑块得分和狭窄的几率显著更高,而不依赖于代谢条件.
- 危险饮酒与更高的CIMT和斑块得分有关,但在对高血压进行调整后,这些影响无意义.
- 与无问题饮酒相比,有害饮酒在动脉样硬化标志物上没有显著差异.
- 不饮酒与较高的CIMT和斑块得分有关.
结论:
- 长期严重的酒精消耗 (药物治疗患者) 似乎直接促进了动脉样硬化.
- 危险饮酒与动脉样硬化的关联很可能是通过高血压.
- 需要进一步的研究来澄清饮酒与血管健康之间的复杂关系.
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