德国医院废水中的耐菌:多药耐药性的储备
Tim Erler1, Laura Carlsen2, Jennifer Dengler3
1Institute for Hygiene and Public Health, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
Scientific reports
|August 27, 2025
概括
在德国医院的废水中发现了耐菌的细菌,包括碳酶基因携带者. 这些抗药性细菌凸显了医疗环境中抗药性监测的必要性.
科学领域:
- 微生物学
- 环境科学
- 临床研究
背景情况:
- 抗菌的细菌是全球越来越严重的健康问题.
- 医疗机构的废水可以作为抗菌素耐药性病原体的储存库.
研究的目的:
- 调查德国三级医院废水中抗杆菌的流行情况和特征.
- 识别与 cefiderocol 耐药性相关的特定细菌物种,耐药性基因和移动基因元素.
主要方法:
- 采用先前化剂对36个废水样本进行培养依赖性分析.
- 对各种抗生素进行抗菌敏感性测试.
- 耐药分离物的全基因组测序和等离子体分析.
主要成果:
- 发现了97个耐醇分离物,主要是Enterobacter roggenkampii,Klebsiella oxytoca,Serratia marcescens和Citrobacter farmeri.
- 大多数隔离物表现出多药性,其中78.5%携带碳酶基因 (例如,blaOXA-48,blaNDM-1,blaVIM-1).
- 在不同类型的等离子体不兼容性之外,还观察到生物杀伤剂和重金属耐药性基因的流行.
结论:
- 医院的废水含有多种耐药细菌,包括含有碳酶基因的细菌,造成耐药性传播的风险.
- 各种抗性基因和移动元素的存在强调了细菌适应具有挑战性的环境.
- 对医疗废水中抗菌素耐药性的持续监测至关重要.
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