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在EAGLE病例控制研究中,过去接触PM10和肺癌风险

Luca Fedrizzi¹, Michele Carugno^2,3, Dario Consonni⁴

¹Department of Clinical Sciences and Community Health, University of Milan, 20122, Milan, Italy.

Scientific reports

|August 27, 2025

概括

这项研究发现1990年长期暴露于颗粒物 (PM10) 与肺癌风险之间没有联系. 然而,最近的PM10暴露仍然与风险增加有关,这表明空气污染可能会促进癌症的发展.

科学领域:

环境流行病学
公共卫生
毒理学

背景情况:

之前的EAGLE研究分析表明,与≤10μm颗粒物 (PM10) 暴露相关的肺癌风险增加.
早期暴露时间窗口对PM10和肺癌风险的相关性仍在调查中.

研究的目的:

通过检查诊断前12-15年的PM10暴露来整合先前的发现 (1990年).
为了比较1990年与2000年PM10暴露与肺癌风险的相关性.
探索空气污染暴露在肺癌致癌过程中的时间相关性.

主要方法:

在EAGLE队列中基于人群的病例控制研究设计.
多变量无条件逻辑回归分析以计算概率比率 (OR) 和95%置信区间 (CI).
1990年和2000年的PM10暴露水平估计,同时对这两个时间段进行相互调整.

主要成果:

与2000年 (46.6μg/m3) 相比,1990年PM10的平均含量更高.
1990年PM10度与肺癌风险之间没有发现显著的关联 (OR: 0. 96, 95%CI: 0. 75-1. 24).
在相互调整后,最近的PM10暴露仍然与肺癌风险增加有关 (OR:1. 49,95%CI:1. 06-2. 08).

结论:

在EAGLE研究中,1990年的PM10暴露与肺癌风险无关.
最近的PM10暴露似乎更相关于肺癌的发展.
这些发现支持空气污染可能成为癌症发展的促成因素的假设,强调最近暴露的重要性.

关键词:

大气污染癌症发生病例对照研究环境健康肺部癌症其他

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