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针对共享β-catenin突变的TCR工程T细胞可以根除固体瘤

Maria Stadheim Eggebø1,2, Julia Heinzelbecker1,2, Heyilimu Palashati1,2

  • 1Department of Cancer Immunology, Oslo University Hospital Radiumhospitalet, Oslo, Norway.

Nature immunology
|August 27, 2025
PubMed
概括

研究人员从CTNNB1突变中发现了新的癌症新抗原. 针对这些新抗原的T细胞在临床前模型中有效地消除了瘤, 为癌症免疫疗法提供了有前途的途径.

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