一个第4阶段的,非随机的,多中心的研究,以评估Optison的静脉注射效果 (和安全性) 以提高对比度的心声学在儿科患者
Arash Sabati1, Shuo Wang2, Pushpa Shivaram3
1Division of Cardiology, Center for Heart Care, Phoenix Children's Hospital, 1919 E Thomas Road, Phoenix, AZ, 85016, USA. asabati@phoenixchildrens.com.
Pediatric cardiology
|August 27, 2025
概括
使用静脉输入Optison的对比增强心声学 (CE-echo) 显著改善了儿科患者的左心室壁片段可视化. 这项研究表明Optison
科学领域:
- 儿童心脏病学
- 医学成像
- 超声波对比剂
背景情况:
- 对于成年人来说,增强对比的心声回声学 (CE-echo) 已经确立,但在儿科中未得到充分利用.
- 对于小儿CE-echo的有效性和最佳剂量存在有限的数据.
- 低于最佳的心声图阻碍了儿童的心脏评估的准确性.
研究的目的:
- 评估输入静脉的Optison对儿科患者的疗效.
- 确定Optison的最佳剂量以改善心声图的质量.
- 评估Optison对内心边界划分 (EBD) 和左心室壁片段 (LVWS) 的影响.
主要方法:
- 这是一项前性,开放的多中心研究,纳入了心声图低于最佳的儿科患者 (9 - 18岁).
- 使用两种Optison剂量的基线非对比心声图 (NC-echo) 之后进行CE-echo.
- 对12个LVWS进行EBD评分,较高的评分表明更好的可视化.
主要成果:
- 在两种剂量中,CE回声显著增加了可视化LVWS的数量 (从3. 7增加到10. 0/10. 5) 并改善了EBD得分 (从11. 9增加到28. 5/30. 2).
- 非最佳心声图率从NC- echo的92. 3%显著降低至26. 2% (剂量1) 和30. 8% (剂量2) (p< 0. 001).
- 包括40公斤以下的儿童,Optison在广泛的儿童体重中表现出有效性.
结论:
- 静脉输入的Optison有效地改善了儿童心声图的LVWS可视化和EBD.
- 两种测试的Optison剂量都提高了心声图的质量,减少了重复或非诊断性研究的需要.
- 在儿童群体中改善心脏成像的Optison是一个有价值的工具.
相关概念视频
Imaging Studies for Cardiovascular System II:Types of Echocardiography
395
Echocardiography plays a role in assessing cardiac health and detecting heart conditions, with various types providing critical insights for diagnosis and treatment.
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for...
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for...
395
Imaging Studies for Cardiovascular System I:Echocardiography
476
Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...
476
Acute Kidney Injury IV: Diagnostic Studies and Prevention
57
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
57
Imaging Studies for Cardiovascular System V: CT
66
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
66
Imaging Studies III: Computed Tomography
50
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
50
Imaging Studies for Cardiovascular System IV: CMRI
135
Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
135


