基于sevoflurane或基于propofol的麻醉对胃癌手术后急性损伤的影响:回顾性倾向评分匹配分析
Yang Song1, Si Liang2,3, Ming Wei1
1Department of Anesthesiology, Harbin Medical University Cancer Hospital, No. 150 Haping Rd., Nangang District, Harbin, 150081, China.
BMC anesthesiology
|August 27, 2025
概括
这项研究在比较基于propofol的静脉全麻醉 (TIVA) 与基于sevoflurane的吸入麻醉 (INHA) 后,没有发现急性损伤 (AKI) 发生率的显著差异. 这两种麻醉方法在术后功能方面表现出相似的安全性.
科学领域:
- 麻醉学
- 肝脏病学
- 外科瘤学
背景情况:
- 急性损伤 (AKI) 是主要腹部手术,特别是胃癌手术后的一种严重并发症.
- AKI与患者死亡率和不良结果的增加有关.
- 确定缓解 AKI 风险的麻醉策略对于改善手术结果至关重要.
研究的目的:
- 在接受胃癌手术的患者中比较术后AKI的发生率.
- 评估基于的静脉全麻醉 (TIVA) 与基于的吸入麻醉 (INHA) 的安全性.
- 确定麻醉选择是否会影响该患者群体的AKI率.
主要方法:
- 哈尔医学大学癌症医院 (2010-2018) 的胃癌手术患者的病历回顾分析.
- 使用倾向分数匹配来创建可比的组.
- 在前3天内对TIVA和INHA组进行了AKI发生率的比较.
主要成果:
- 最初包括3533名患者;每组麻醉剂有1206名患者.
- 在匹配前 (OR1. 05) 和匹配后 (OR1. 02) 的两组中,物流回归没有显示出AKI发生率的显著差异.
- 在匹配后,sevoflurane的AKI发病率为5. 0%和propofol的5. 1%,表明可比率.
结论:
- 这项回顾性研究表明,经过胃切除术后,术后AKI发生率没有显著差异.
- 在胃癌手术患者中,基于的TIVA和基于的INHA似乎具有相似的AKI风险.
- 在胃切除术后,选择使用和西沃之间的麻醉剂不会显著影响AKI的发生概率.
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