消化系统瘤患者的营养风险评估指数的预测值
Tingting Zeng1, Xiaolan Ling1, Si Chen1
1Department of Laboratory Medicine, West China Hospital; Sichuan University, Sichuan Clinical Research Center for Laboratory Medicine; Clinical Laboratory Medicine Research Center of West China Hospital, 37# Guoxue Xiang, Chengdu, Sichuan, PR China.
在消化系统瘤患者中,营养风险很常见,影响生存率. 三个指数 (CONUT,NRI,PNI) 可以帮助评估风险和预后,特别是在胃癌中,尽管它们在其他消化系统瘤中的应用有限.
科学领域:
- 癌症学
- 营养科学
- 医学统计
背景情况:
- 在消化系统瘤 (DST) 中,营养风险评估指数的预后意义尚未得到充分确立.
- 手术前的营养状况对于癌症患者的治疗结果至关重要.
研究的目的:
- 评估三种营养风险评估指数在新诊断的DST患者中的预后作用.
- 确定各种疾病中营养风险的普遍性及其与死亡率的关联.
主要方法:
- 对17338名患有10种DST的患者进行了回顾性分析.
- 在手术前使用控制营养状况 (CONUT) 评分,营养风险指数 (NRI) 和预后营养指数 (PNI).
- 检查营养风险指数与患者死亡率之间的相关性.
主要成果:
- 在DST中观察到营养风险的高患病率 (CONUT为79.24%,NRI为38.91%,PNI为3.13%).
- 在胃癌患者中,CONUT,NRI和PNI有效地分层预后,独立于其他因素.
- 在肝内胆管癌中,CONUT具有预后价值;在食道癌和胰腺癌中,NRI具有显著意义.
结论:
- 在DST患者中,营养风险普遍存在,并与死亡率增加有关,特别是在胃癌中.
- 营养风险评估指数需要更多的注意力来改善DST患者的预后.
- 需要进一步的临床试验来评估营养干预措施,特别是胃癌.
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