相关实验视频
Updated: Sep 10, 2025

Visualization of Cortical Modules in Flattened Mammalian Cortices
Published on: January 22, 2018
通过整合性蛋白质组和连接组分析揭示的与语言相关的皮质区域的分子结构
Jinsong Wu1, Zixian Wang2,3, Fengjiao Li4
1Glioma Surgery Division, Neurological Surgery Department of Huashan Hospital, Fudan University, Shanghai, China.
大脑蛋白质表达在半球内不同,影响语言网络连接. 质瘤患者表现出右半球补偿, 将分子形状与功能重组联系起来.
科学领域:
- 神经科学
- 蛋白质组学
- 大脑连接
背景情况:
- 假设蛋白质表达中的半球不对称会影响功能连接.
- 在质瘤中语言网络和大脑重组中的分子差异的作用尚不清楚.
研究的目的:
- 研究与语言相关的大脑区域的半球蛋白质表达差异.
- 为了将蛋白质组的形状与大脑的功能和结构连接性联系起来.
- 研究质瘤患者的大脑重组和补偿机制.
主要方法:
- 使用无标签的双重质谱分析了来自捐赠大脑的与语言相关的布罗德曼区域 (BA) 的蛋白质特征.
- 蛋白质组形状与人类结合体项目的静止状态连接数据进行了比较.
- 通过与语言表现相关的对侧灰质体积来评估质瘤患者的功能补偿.
主要成果:
- 半球内蛋白质表达异质性大于同类区域之间的异质性.
- 功能连接强度与蛋白质表达相似,与半球突触调节的差异相关 (GRIA1/GRIA4).
- 质瘤患者表现出右半球补偿,维尼克的同类灰质体积与语言功能相关.
结论:
- 蛋白质表达的相似性和连接体结构表现出同型混合效应.
- 语言区域的不同蛋白质特征有助于功能连接.
- 分子形状与质瘤的功能重组和补偿有关.
更多相关视频
10:36High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning
Published on: December 15, 2016
07:52Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents
Published on: May 23, 2025
相关概念视频
Higher Mental Functions of the Brain: Language
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
Association Areas of the Cortex
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Motor and Sensory Areas of the Cortex
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
Somatosensory, Motor, and Association Cortex
Proteomics
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
Language and Cognition