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研究领域工程学化学工程能源和燃烧中的化学和热过程
细胞外乳酸通过在低氧条件下调节H3K9乳酸和SnoN表达来改善神经发生

细胞外乳酸通过在低氧条件下调节H3K9乳酸和SnoN表达来改善神经发生

Wenhong Xu ¹, Anqi Zhao ¹, Rui Han ², Junyuan Wei ¹, Qi Yu ¹, Miaomiao Wang ¹, Haokun Li ¹, Baofeng Xu ³, Meiying Li ⁴, Guangfan Chi ⁵

Wenhong Xu ¹, Anqi Zhao ¹, Rui Han ²

¹The Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, 130021, China.
²The Department of Neurovascular Surgery, First Hospital of Jilin University, Changchun, 130021, China.
³Stroke Center, Department of Neurology, First Hospital of Jilin University, Changchun, 130021, China. xubf@jlu.edu.cn.
⁴The Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, 130021, China. Meiying@jlu.edu.cn.
⁵The Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, 130021, China. guangfan130@jlu.edu.cn.

⁰The Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, 130021, China.

Stem Cell Research & Therapy +

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2025年八月27日

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在PubMed上查看摘要

概括

此摘要是机器生成的。

在低氧状态下,L-乳酸通过基因素乳化 (H3K9la) 和SnoN蛋白促进神经发生. 这种途径突出了神经恢复的潜在治疗目标.

科学领域

神经科学
生物化学
干细胞生物学

背景情况

乳酸有利于成人的神经发生,并调解蛋白质的乳化.
基因素乳化在神经发生过程中的作用尚不清楚.
研究乳酸对神经干细胞 (NSC) 和基因素乳化的影响至关重要.

研究的目的

解释乳酸和NSC命运之间的关系.
在神经发生过程中探索基因素乳酸的作用.

主要方法

在低毒性条件下用乳酸治疗NSC.
使用了西斑,免疫光,RNA测序和ChIP测序.
分析了基因表达的变化.

主要成果

在低氧状态下,L- 乳酸促进了神经发生,并诱导了H3K9 histone乳化 (H3K9la).
抑制L-乳酸或H3K9la会影响神经元发育和NSC分化.
H3K9la在SnoN促进体中得到丰富,并且SnoN抑制降低了双丁 (DCX) +神经元的产生.

结论

在低氧条件下,L-乳酸通过H3K9la/SnoN途径促进神经发生.
SnoN被认为是乳酸诱导神经发生的关键媒介.
H3K9la/SnoN轴是神经恢复的潜在治疗点,特别是在脑缺血中.

关键词:

大脑缺血 H3K9 病毒乳酸盐乳化神经干细胞美国

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