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代谢异质性导致瘤微环境的差异

Juliana de Souza do Nascimento^1,2, João Figueira Scarini^1,2, Erika Said Abu Egal^1,3

¹Department of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), São Paulo, Brazil.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

|August 28, 2025

概括

与口腔黑色素瘤相比,鼻腔黑色素瘤表现出不同的代谢特征,通常表现出较高的脂肪素表达. 在皮肤黑色素瘤中,转移性瘤中的脂肪酸合成酶 (FASN) 表达表明在疾病进展中起作用.

科学领域:

癌症学
癌症新陈代谢
黑色素瘤研究

背景情况:

黑色素瘤是一种皮肤和粘膜癌,可能是侵袭性的,特别是晚期的皮肤瘤或鼻腔/口腔粘膜病变.
癌细胞重新编程能量代谢,
了解不同黑色素瘤亚型的代谢变化对于向治疗至关重要.

研究的目的:

在鼻腔黑色素瘤 (SM),口腔黑色素瘤 (OM) 和皮肤黑色素瘤 (CM) 中研究关键代谢和扩散蛋白的表达.
将这些标志物与原发性瘤,转移性病变和良性黑色细胞瘤进行比较.
阐明新陈代谢重编程在黑色素瘤进展中的作用.

主要方法:

对阿迪波菲林,FASN,GLUT-1,HIF-1α和Ki-67进行免疫组织化学分析.
这项研究包括28个SM,16个OM,39个CM (具有匹配的淋巴结转移),以及良性黑色细胞瘤对照.
瘤亚型,转移状态和对照组之间的比较分析.

主要成果:

与OM相比,SM表现出更多的未分化细胞,死亡和更高的脂蛋白表达.
转移性CM显示FASN表达增加,尽管与原发性瘤没有显著差异.
在转移性CM中,Ki-67的扩散指数较低;良性病变的总体标记表达较低.

结论:

SM和OM表现出不同的代谢表型,SM经常对基素呈阳性.
在转移性CM中增加FASN表达表明其可能对疾病进展作出贡献.
根据黑色素瘤亚型和转移潜力,代谢蛋白质的表达有所不同.

关键词:

皮肤黑色素瘤葡萄糖生成脂肪生成代谢过程口腔黑色素瘤鼻腔黑色素瘤

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