淋巴血管侵入 (LVI) 与胃食道结合腺癌的系统性免疫炎症指数 (SII) 相对应:对预后分层的影响
Gerd Jomrich1, Winny Yan1, Dagmar Kollmann1
1Department of General Surgery, Gastroesophageal Tumor Unit-Comprehensive Cancer Center (CCC), Medical University of Vienna, 1090 Vienna, Austria.
Cancers
|August 28, 2025
概括
该研究发现,结合SII (系统性免疫炎症值) 和LVI (淋巴血管入侵) 可以改善胃食道结腺癌的预后,特别是在接受前期手术的患者中.
科学领域:
- 癌症学
- 外科瘤学
- 胃肠癌研究
背景情况:
- 胃食道结节腺癌 (AEG) 是一种侵袭性恶性瘤,发病率越来越高,存活率较低.
- 目前的多种治疗方法缺乏可靠的手术前预后标志物.
- 准确的预后分层对于个性化治疗和随访计划至关重要.
研究的目的:
- 评估AEG患者的系统性免疫炎症值 (SII) 和淋巴血管侵袭 (LVI) 之间的关联.
- 评估SII和LVI对AEG总生存的综合预后值.
- 确定SII和LVI作为预后标志物的有用性,特别是在治疗策略方面 (前期手术与新辅助疗法).
主要方法:
- 一个前性地维护的机构数据库的回顾性分析.
- 包括211名为AEG进行治疗切除的患者.
- 评估SII和LVI的相关性和综合预后值.
主要成果:
- 淋巴血管侵袭 (LVI) 在45%的患者中存在,并且与显著更高的SII值相关.
- 较高的SII和LVI独立地与较低的整体存活率有关 (p < 0. 001).
- 在接受前期手术的患者中,高SII和LVI的组合确定了预后特别差的亚组.
- 在接受新辅助治疗的患者中,SII仍然是一个强烈的预后因素,但LVI的意义下降.
结论:
- 结合SII和LVI的评估可以提高AEG的预后分层,特别是对于接受前期手术的患者.
- 这些标记可能有助于个性化治疗和AEG患者的后续计划.
- 这是第一个研究SII和LVI在AEG中的联合关联.
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