来自大米树残留物中的氨酸的癌症预防性质 针对由化学物质诱导的小鼠肝脏和结肠癌的早期阶段
Aroonrat Pharapirom1, Sirinya Taya2, Arpamas Vachiraarunwong1,3
1Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Cancers
|August 28, 2025
概括
通过减少大鼠肝脏和结肠的先发性病变,米谷蛋白水解剂 (GTLH) 显示出抗癌作用. GTLH抑制细胞增殖并促进细胞灭绝,这表明它有可能成为预防癌症的食补充剂.
科学领域:
- 生物化学
- 分子生物学
- 癌症研究
背景情况:
- 米蛋白和水解物具有抗癌性质.
- 米谷蛋白 (GTL) 和其水解物 (GTLH) 在体外显示出抗氧化和抗变异作用.
- 之前没有研究过GTL和GTLH在体内癌症的化学预防作用.
研究的目的:
- 调查米谷蛋白 (GTL) 和其水解剂 (GTLH) 的癌症化学预防机制.
- 评估它们对大鼠肝脏和结肠中二甲基氨酸 (DEN) 和1,2-二甲基氨酸 (DMH) 诱导的前瘤病变的影响.
主要方法:
- 在大鼠中,GTL,GTLH或总蛋白质水解剂 (TPH) 剂量为500mg/kg,持续10周.
- 通过量化肝脏中的S转移酶胎盘形式 (GST-P) 阳性焦点和结肠中的异常密码焦点 (ACF) 来评估化学预防作用.
- 分析了细胞增殖 (PCNA) 和细胞亡 (TUNEL),以及BAX和CASP3基因的表达.
主要成果:
- GTLH显著减少了肝脏中的GST- P阳性焦点和结肠中的ACF.
- GTL 减少了肝脏中的 GST- P 阳性焦点,但没有在结肠中的 ACF;TPH 没有显著的影响.
- 在两个器官中抑制细胞增殖并诱导细胞亡,在肝脏上调BAX和CASP3,在结肠上调BAX.
结论:
- 在动物模型中,米谷蛋白水解剂 (GTLH) 具有显著的癌症化学预防潜力.
- 通过抑制细胞增殖和促进肝脏和结肠的亡,GTLH减少了先性病变.
- GTLH可以作为功能性食品成分或用于预防癌症的食补充剂.
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