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研究领域生物医学和临床科学瘤学和致癌症预测和预后标志物
在多发性骨髓瘤中开发细胞遗传双击模型的生存预测

在多发性骨髓瘤中开发细胞遗传双击模型的生存预测

Chenxing Du ^1,2, Jian Cui ^1,2,3, Jingyu Xu ^1,2,3, Wenqiang Yan ^1,2, Lingna Li ^1,2, Weiwei Sui ^1,2, Shuhui Deng ^1,2, Shuhua Yi ^1,2, Yan Xu ^1,2, Chengwen Li ^1,2, Jiawei Zhao ^1,2, Dehui Zou ^1,2, Lugui Qiu ^1,2, Gang An ^1,2

Chenxing Du ^1,2, Jian Cui ^1,2,3, Jingyu Xu ^1,2,3

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
²Tianjin Institutes of Health Science, Tianjin 301600, China.
³LeBow Institute for Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.

⁰State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.

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2025年八月28日

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在PubMed上查看摘要

概括

此摘要是机器生成的。

一个新的HBDH双击模型识别了具有多重高风险染色体异常 (HRCAs) 的超高风险多发性骨髓瘤 (MM) 患者. 这种模型为无进展生存和整体生存提供了改进的预后分层.

科学领域

血液学
遗传学
癌症学

背景情况

高危染色体异常 (HRCAs) 显著影响多发性骨髓瘤 (MM) 的预后.
多个HRCAs的共存定义了MM中的低风险子组,称为双重或多重打击MM.
目前还没有对双击MM的标准化定义.

研究的目的

根据特定的HRCAs来定义双击MM.
开发和验证一个新的预后模型,HBDH双击模型.
评估该模型在MM中无进展生存期 (PFS) 和整体生存期 (OS) 的预后值.

主要方法

对1122名新诊断的MM患者的回顾性分析 (2008年至2019年).
双击MM的定义:至少有两个HRCAs (t(14;16),gain(1q),del(17p),del(1p) 的同时存在.
对PFS和OS的HBDH双击模型的构建和评估.

主要成果

双重感染的MM患者表现明显较差:PFS中位数为20. 6个月与53. 3个月,OS中位数为40. 2个月与84. 2个月 (p < 0. 001).
包括del{13q},t{4;14) 或t{11;14) 并没有提高模型的预测性能.
该HBDH模型的预测独立于ISS,LDH水平和晚年.

结论

双击HBDH模型有效地识别了具有多个HRCAs的超高风险MM子集.
它为MM的预后分层提供了一个简单,强大的框架.
这种模式可以作为未来的向性治疗策略的参考.

关键词:

细胞遗传异常双重打击在现场混合的相间光多发性骨髓瘤预后情况

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The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

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