维生素D作为精神分裂症的可修改风险因素
Jadwiga Mosiołek1,2, Bartosz Mosiołek3, Agata Szulc1,2
1Faculty of Health Sciences, Medical University of Warsaw, Żwirki i Wigury 61, 02-091 Warsaw, Poland.
Biomolecules
|August 28, 2025
概括
新生儿维生素D水平低与精神分裂症风险有关. 成年人维生素D缺乏与大脑灰质减少和骨健康不佳相关,但代谢综合征的风险增加.
科学领域:
- 神经科学
- 营养心理医学
- 公共卫生
背景情况:
- 精神分裂症的病因复杂, 预防策略有限.
- 营养不良和维生素D缺乏被认为是潜在的危险因素.
- 维生素D对神经发育和心理健康的作用越来越被认可.
研究的目的:
- 审查不同生命阶段的维生素D状况与精神分裂症风险之间的关联.
- 研究维生素D对精神分裂症的神经生物学,药物动力学和代谢方面的影响.
- 综合了2000年至2024年的维生素D和精神分裂症的现有证据.
主要方法:
- 在PubMed和Web of Science数据库进行系统的文献搜索.
- 遵守PRISMA研究选择和数据提取指南.
- 包括2000年至2024年间发表的研究.
主要成果:
- 没有发现母亲维生素D水平与后代精神分裂症风险之间的显著相关性.
- 新生儿维生素D水平较低与晚年精神分裂症有正相关性.
- 成年人维生素D缺乏 (低于20 ng/mL) 与灰质体积减少,骨健康不佳以及代谢综合征患病率较高有关.
- 维生素D水平与抗精神病药物度相关.
结论:
- 新生儿维生素D水平可能是精神分裂症发展的关键因素.
- 在精神分裂症的背景下,成人维生素D缺乏对大脑结构,骨健康和代谢健康有影响.
- 需要进一步研究以阐明维生素D在精神分裂症预防和治疗中的精确机制和治疗潜力.
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