在青春期内化和外化特征:使用表观遗传学和周围风险来区分症状集群
Maddalena Mauri1, Silvia Grazioli2,3, Carolina Bonivento4
1Child Psychopathology Unit, Scientific Institute, IRCCS Eugenio Medea, 23842 Bosisio Parini, Italy.
Biomolecules
|August 28, 2025
概括
具有高度内化和外化问题的青少年表现出更多的围产并发症和关键基因的DNA甲基化变化. 早期的不良反应与青少年的精神病理和表观遗传变化有关.
科学领域:
- 发展心理学
- 分子精神病学
- 行为遗传学
背景情况:
- 青春期是内化和外化行为问题的关键时期.
- 了解不同心理病理特征及其潜在的生物机制对于有针对性的干预至关重要.
- 环境因素和表观遗传修饰越来越多地被认为是精神病理的重要贡献者.
研究的目的:
- 确定青少年内化和外化特征的不同集群.
- 检查已识别的集群与环境风险因素之间的联系.
- 调查表观遗传特征的差异,特别是DNA甲基化,跨集群.
主要方法:
- 对205名被转诊为儿童精神病理的青少年进行横截面研究.
- 使用儿童行为检查表/6-18 (CBCL) 评估的行为问题.
- 用于集群分析的有限混合物建模;用于组比较的 χ2 试验和 Bonferroni 校正的 t 试验.
主要成果:
- 确定了两个青少年精神病理群:低 (亚临床症状) 和高 (高度内化/外化症状).
- 在HIGH群中,产周并发症显著增加.
- HIGH 集群显示脑衍生神经营养因子 (BDNF),胰岛素类生长因子-2 (IGF2) 和氧化素受体 (OXTR) 的CpG位点的甲基化发生变化,但没有FK506结合蛋白5 (FKBP5).
结论:
- 在早期不良事件,DNA甲基化模式和青少年精神病理之间存在强烈的关联.
- 像BDNF,IGF2和OXTR这样的基因的特定表观遗传修饰可能会调解早期逆境和行为问题之间的联系.
- 这些发现突显了环境和表观遗传因素在青少年行为问题发展中的相互作用.
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