糖酸可缓解肉死肠炎的感染
Theros T Ng1, Brandi A Sparling1, Ramesh K Selvaraj2
1College of Veterinary Medicine, Western University of Health Sciences, Pomona, CA 91766, USA.
Animals : an open access journal from MDPI
|August 28, 2025
概括
糖酸 (ZG) 补充剂改善了的生长,并减少了死肠炎 (NE) 的严重程度. 在家禽料中的最佳ZG含量可以改善鸟类的健康并降低死亡率.
科学领域:
- 禽类营养和免疫学
- 动物病理学和疾病控制
- 动物的胃肠道健康
背景情况:
- 死亡性肠炎 (NE) 对家禽的健康和经济生存构成重大威胁.
- 了解等特定营养素在减轻NE中的作用至关重要.
- 糖酸 (ZG) 是一种改善健康的潜在食补充剂.
研究的目的:
- 评估糖酸盐 (ZG) 在预防和治疗死肠炎 (NE) 的有效性.
- 确定最佳的ZG补充水平以改善生长性能和减少与NE相关的病理.
- 研究对肠道细胞活性的体外影响.
主要方法:
- 用肉补充不同剂量的ZG (40-160 mg/kg) 的两次体内实验.
- 一个体外实验评估了对HD-11肠道细胞的影响,该实验使用了Clostridium perfringens.
- 测量包括体重增加 (BWG),料转化率 (FCR),病变得分,死亡率和免疫基因表达 (IFN-γ,SOD1).
主要成果:
- 120 mg/kg的ZG补充剂显著改善了BWG,并减少了NE病变.
- 采用80 mg/ kg和120 mg/ kg的剂量,死亡率较低.
- 在C. perfringens的试验中,增强了肠道细胞活力,降低了细胞毒性.
- ZG调节免疫反应,增加IFN-γ并降低Zn/ Cu SOD1表达.
结论:
- 糖酸 (ZG) 有效缓解死性肠炎.
- 建议饮食中ZG含量为120 mg/kg,以实现禽类的最佳性能和疾病控制.
- 需要进一步研究对家禽的免疫调节作用.
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