在断奶小猪中,低剂量的柏柏林被新陈代谢,肠道形态或肠道微生物群没有发生重大变化
Christina Mouchtoglou1, Marc Cherlet2, Tessa Dehau1,3
1Livestock Gut Health Team (LiGHT) Ghent, Department of Pathobiology, Pharmacology and Zoological Medicine, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium.
Animals : an open access journal from MDPI
|August 28, 2025
概括
贝贝林 (BBR) 正在作为小猪肠道健康的氧化替代品进行研究. 虽然小猪代谢BBR,但低剂量并没有改善断奶猪的肠道组织形态,微生物群或短链脂肪酸的产生.
科学领域:
- 动物科学
- 动物医学
- 药理学
背景情况:
- 由于压力因素, 断奶小猪面临严重的肠道健康问题.
- 此前用于断奶后腹的氧化 (ZnO) 自2022年以来在欧盟被禁止使用.
- 柏柏林 (BBR) 是一种天然化物,由于其历史的使用和药理性质,它被认为是ZnO的安全替代品.
研究的目的:
- 在断奶小猪的肠道和肝脏中研究柏柏林的代谢.
- 在肠道和血中识别贝贝林代谢物.
- 评估低剂量柏柏林补充剂对小猪组织形态,短链脂肪酸 (SCFA) 生产和肠道微生物群组成的影响.
主要方法:
- 六十只4周大的小猪分为控制组和柏柏林 (BBR) 组 (30mg/kg料) 两周.
- 在肠道含量和血中使用超高性能液态染色体- 双重质谱 (UPLC- MS/ MS) 来量化柏柏林及其代谢物.
- 分析了基因组学参数 (体长度,密室深度),SCFA产量和肠道微生物群组成 (16S rRNA测序).
主要成果:
- 小猪成功地将贝贝林代谢成I期和II期代谢物.
- 检测到的柏柏林代谢物存在于肠道和血中.
- 低饮食剂量的柏柏林并没有显著改变组织形态参数,SCFA的产生,或状,状和结肠微生物群的组成.
结论:
- 断奶的小猪可以代谢贝贝林,产生可检测的代谢物.
- 测试的低剂量柏柏林似乎对断奶小猪的肠道健康标志物没有带来好处.
- 需要进行进一步的研究,以探讨贝贝林在小猪中的潜在治疗效果.
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