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通过表面工程提高Ceria纳米粒子在生物环境中的抗氧化剂性能

Pierluigi Lasala¹, Tiziana Latronico², Umberto Mattia¹

¹Chemistry Department, University of Bari, Via Orabona 4, 70126 Bari, Italy.

Antioxidants (Basel, Switzerland)

|August 28, 2025

概括

用多巴胺对氧化 (CeO_2-x) 纳米粒子进行表面工程,以增强其在生物环境中的抗氧化特性. 这种方法通过引入o-子结构来改善细胞内活性氧物种 (ROS) 的减少,从而提高了子纳米粒子的有效性.

科学领域:

纳米技术
材料科学
生物医学工程

背景情况:

Ceria (CeO_2-x) 纳米粒子 (NP) 是一个有前途的纳米抗氧化剂.
优化它们的结构和表面特性对于生物应用至关重要.
表面工程可以增强CeO2-xNP的内在抗氧化能力.

研究的目的:

合成具有高Ce3+/Ce4+比率的水中可分散的CeO2-xNP.
通过对多巴胺进行表面功能化来增强CeO2-xNP的抗氧化行为.
评估表面修改对细胞环境中的ROS清理的影响.

主要方法:

在非极性溶剂中合成超小的CeO2-xNP.
使用酸转化为水溶液 (CeO_2-x@Cit).
用多巴胺 (CeO_2-x@Dopa) 进行表面功能化后处理.
使用UV-vis,FT-IR和XPS光谱进行表征.
在神经细胞中评估DPPH激素清除活性和细胞内ROS水平.

主要成果:

与CeO_2-x@Cit相比,Dopa NPs表现出较低的DPPH激素清除能力.
在神经细胞中,dopa显著降低了细胞内ROS水平 (35%对66%).
用多巴胺和其o-胺结构的表面功能增强了细胞环境中的抗氧化活性.

结论:

使用多巴胺和o-结构的CeO2-xNP的表面工程提高了它们在生物系统中的抗氧化功效.
这些o-基因组有助于打破自氧化链,补充CeO_2-xNP的内在特性.
这一战略为开发用于生物医学应用的先进纳米抗氧化剂提供了有价值的方法.

关键词:

基和基基自氧化链断裂的纳米粒子抗氧化剂研究的非酶定量

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