由于减肥压力而导致的功能受损与过度食用林奈斯
Linaloe Manzano-Pech1, María Elena Soto2, Vicente Castrejón-Tellez3
1Department of Physiology and Pharmacology UNAM, Facultad de Medicina y Veterinaria y Zootecnia, Av. Universidad 3000, Coyoacán 04510, Mexico.
Antioxidants (Basel, Switzerland)
|August 28, 2025
概括
过度食用西红 (HSL) 可能会导致减少压力 (RS),因为它会过载抗氧化剂系统. 这项研究发现,大鼠的高HSL摄入导致RS,矛盾地减少了反应性氧物种 (ROS).
科学领域:
- 生物化学
- 生理学
- 药理学
背景情况:
- 减少性压力 (RS) 源于抗氧化系统的失衡,可能是由过度摄入抗氧化剂引起的.
- 这种植物含有丰富的抗氧化剂,
- 了解高抗氧化剂消耗对氧化平衡的影响对于健康至关重要.
研究的目的:
- 研究过度食用Hibiscus sabdariffa (HSL) 对Wistar大鼠减轻压力的影响.
- 评估HSL对血管抵抗 (RVR) 和抗氧化酶活性的影响.
- 为了确定高HSL摄入量是否导致反应性氧物种 (ROS) 的减少.
主要方法:
- 21只Wistar大鼠被分为三个组:HSL输液 (6%),HSL接着是水,和对照组 (仅用水).
- 通过对上腺素,乙胆,超氧化物,过氧化和过氧的反应来评估血管耐药性 (RVR).
- 测量了抗氧化酶和氧化应激标志物的活性,包括GSH/GSSG比率和酸盐/酸盐.
主要成果:
- 通过各种药物调节RVR,由上腺素和过氧化增加,由乙胆,超氧化和过氧化减少.
- 关键的抗氧化标志物,包括降低的谷氨/氧化谷氨 (GSH/GSSG) 比率,总抗氧化能力和几个酶活性,在HSL消费组中升高.
- 相反,与对照组相比,在食用HSL的老鼠中,醇组和S转移酶活性下降.
结论:
- 过度摄入6%的Hibiscus sabdariffa (HSL) 输液中的抗氧化剂会在老鼠中诱导减少压力 (RS).
- 尽管抗氧化系统过载,RS的这种状态导致反应性氧物种 (ROS) 的矛盾性减少.
- 这些发现突显了抗氧化剂过度消耗的潜在风险,导致新陈代谢失衡和血管反应改变.
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