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基因组洞察新兴多药耐药的菌株:泰国第一份报告

Orathai Yinsai^1,2, Sastra Yuantrakul², Punnaporn Srisithan²

¹Office of Research Administration, Chiang Mai University, Chiang Mai 50200, Thailand.

Antibiotics (Basel, Switzerland)

|August 28, 2025

概括

多种药物耐药的Chryseobacterium 印度基因正成为泰国医院的重大威胁. 基因组分析显示了与广泛的抗药性相关的大型基因组岛屿,凸显了监测的必要性.

科学领域:

微生物学
基因组学
传染性疾病

背景情况:

菌是一种新兴的医院病原体,特别是在亚洲.
这种细菌通常具有多药性耐药性 (MDR).

研究的目的:

来自泰国的临床C. indologenes分离物的基因组特征.
了解多药性耐药性机制,病毒性因素和移动遗传元素 (MGE).

主要方法:

使用混合方法 (Illumina和牛津纳米孔) 的全基因组测序 (WGS).
对抗微生物耐药性 (AMR) 基因,毒性因子和MGE组装基因组的分析.

主要成果:

十二种C. indologenes分离物表现出广泛的耐药性,与基因组决定因素相关.
在大多数隔离物中发现了携带显著抗药基因的大型基因组岛屿 (94-100 kb),与广泛耐药 (XDR) 表型相关.
遗传学分析显示,大多数分离物与中国菌株结合在一起,除了一种具有较低的耐药性.

结论:

在泰国医院出现了多种抗药性C.
基因组洞察力揭示了通过大型基因组岛屿的特定抵抗机制和潜在的水平基因转移 (HGT).
持续的基因组监测对于监测传播和制定有效的治疗策略至关重要.

关键词:

杆菌印度基因抗菌耐药性基因新出现的病原体具有广泛的耐药性横向基因转移移动的遗传元素医院感染全基因组测序

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