在爱尔兰群体中,用多西环素进行木四重治疗是有效的第一线治疗
Conor Costigan1,2, Mark Comerford2, Ronan Whitmarsh3
1Trinity Academic Gastroenterology Group, Trinity College, D02 R590 Dublin, Ireland.
Antibiotics (Basel, Switzerland)
|August 28, 2025
概括
在爱尔兰,用多西环素 (BQT-D) 进行的四重治疗有效地消灭了Helicobacter pylori,即使具有高抗生素耐药性,作为一线治疗也取得了90%以上的成功. 这种治疗方案对感染H. pylori的患者有希望.
科学领域:
- 胃肠病与传染病
- 微生物学与抗菌药物耐药性
- 临床治疗方法
背景情况:
- 由于抗生素耐药性增加,特别是对克拉里素和甲醇的抗生素耐药性,Helicobacter pylori的根除率下降.
- 在爱尔兰,由于石的有限供应和对四环素的限制,需要探索替代BQT配方.
- 马斯特里赫特VI/佛罗伦萨指南建议BQT用于高抗性区域的第一线治疗.
研究的目的:
- 在爱尔兰患者队列中评估使用多西环素 (BQT-D) 修饰的石四倍疗法的疗效.
- 评估BQT-D作为H. pylori感染的第一线和后续线治疗的有效性.
主要方法:
- 这项前性研究涉及3个爱尔兰中心的217名H. pylori感染患者.
- 使用的治疗方法:14天的BQT-D疗程 (比斯木亚酸盐,美特罗尼达,多西环素,埃索梅普拉).
- 在治疗后通过尿素呼吸试验或便抗原测试确认了消灭.
主要成果:
- 在接受BQT- D作为第一线治疗的前治疗患者中,消除率高达92% (165/ 180).
- 在接受BQT- D作为二线治疗的患者中,成功消除了76% (22/ 29) 和88% (7/ 8) 的患者作为救援治疗.
- 没有报告严重的不良反应;由于每日多次剂量,6. 5%的患者发现治疗方案复杂.
结论:
- 在具有显著的双抗生素耐药性的人群中,BQT-D作为一线治疗的高效率 (> 90%).
- 与一线治疗相比,BQT-D作为二线治疗的效果有所下降.
- 该研究支持使用BQT-D作为爱尔兰H. pylori根除的可行和有效的第一线策略.
相关概念视频
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