在接受化疗的急性髓性白血病患者中,与微生物组破坏和随后的抗生素耐药性感染和殖民事件相关的抗生素管理因素的表征
Samantha Franklin1, Corina Ramont2, Maliha Batool3
1Interdisciplinary Graduate Program in Genetics and Genomics, Texas A&M University, College Station, TX 77843, USA.
Antibiotics (Basel, Switzerland)
|August 28, 2025
概括
在接受化疗的急性髓性白血病 (AML) 患者中使用抗生素会影响微生物多样性和耐药性. 某些抗生素可能会降低抗药性基因的获取,但总体效果不同.
科学领域:
- 微生物学
- 癌症学
- 药理学
背景情况:
- 广泛的抗生素对于怀疑感染的血液恶性病患者至关重要.
- 抗生素使用可能会导致抗菌素耐药性和微生物组失调.
- 在接受缓解诱导化疗 (RIC) 的急性髓性白血病 (AML) 患者中,抗生素对微生物组和抗体的影响尚不清楚.
研究的目的:
- 在接受RIC的AML患者中研究抗生素给药对微生物组和抗体的影响.
- 分析抗生素耐药性感染 (ARI) 和疾病预防控制中心威胁的殖民化 (ARC) 的差异.
主要方法:
- 使用统计模型检查微生物组和耐药组随时间变化.
- 分析包括119名接受RIC治疗的AML患者.
- 研究了抗生素类别,多样性和抗生素耐药性基因 (ARG) 之间的相关性.
主要成果:
- 更多独特的抗生素类与较少独特的ARG相关 (R = - 0.39, p = 0.008).
- 氧化的使用与微生物多样性的减少相关 (R = - 0.58, p < 0.001).
- 每天的线索利德降低了约30%的ARC风险 (HR: 0. 663, p = 0. 047) 和宏素耐药基因的获得率 (HR: 0.50, p = 0. 026).
结论:
- 抗生素的使用和类型影响AML患者的ARG扩张和ARC事件.
- 一些抗生素可能会减少微生物多样性而不会增加ARG或ARC事件.
- 了解这些动态对于管理AML患者的感染和耐药性至关重要.
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