临终期患者使用抗生素的益处和危害:息治疗中的回顾性研究
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在PubMed上查看摘要
概括
此摘要是机器生成的。抗生素可以帮助控制症状并改善息治疗患者的生活质量. 西普洛克萨显示出最好的症状控制,但需要对抗生素在终身护理中的使用进行更多研究.
科学领域
- 缓和护理
- 药理学
- 临床研究
背景情况
- 抗生素经常用于终身护理,以控制症状并提高生活质量.
- 然而,对于这种患者群体的抗生素决策缺乏明确的指南.
- 这项研究解决了缓解性抗生素治疗中基于证据的做法的需要.
研究的目的
- 对接受社区息治疗的患者使用抗生素的益处和危害进行评估.
- 为了比较常见的抗生素对生存,症状强度和功能状态的有效性.
- 为临床决策提供有关终身护理中的抗生素处方的信息.
主要方法
- 在两年内对249名已故患者进行了观察性,横截面的回顾性研究.
- 收集关于人口统计,诊断,抗生素处方和症状结果的数据.
- 统计分析比较了阿莫西西林 + 克拉夫兰酸,塞菲西姆,西普罗夫洛克萨辛和利沃弗洛克萨辛的生存和症状尺度.
主要成果
- 33. 7% 的患者接受了抗生素治疗; 57. 8% 的患者出现了不良反应 (感染,分泌物).
- 在抗生素组之间没有发现显著的生存差异 (p = 0. 990).
- 症状强度在72小时内显著下降 (p < 0. 05),而西普罗夫洛克萨辛显示出更好的控制. 对不同抗生素的反应不同.
结论
- 抗生素有助于改善临终护理中的症状控制和生活质量.
- 第二线抗生素可能有额外的益处, 但进一步的研究是必不可少的.
- 样本的异质性和有限的不良事件数据凸显了需要改进的息治疗抗生素指导方针.
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