在医院环境中监测和鉴定抗菌素和抗菌素可变肠杆菌
Claudia Rotondo1, Valentina Antonelli1, Alberto Rossi1
1Microbiology and Biobank Unit, National Institute for Infectious Diseases "Lazzaro Spallanzani", IRCCS, 00149 Rome, Italy.
Antibiotics (Basel, Switzerland)
|August 28, 2025
概括
在医院中,常见的是抗旺素的肠球菌 (VRE) 和抗旺素的变异性肠球菌 (VVE). 这项研究强调需要加强监测和感染控制以对抗这些耐药菌株.
科学领域:
- 微生物学
- 传染性疾病
- 基因组学
背景情况:
- 包括E. faecalis和E. faecium在内的肠球菌会导致严重的医院感染.
- 由于抗生素耐药性,越来越多的VRE和VVE带来了重大挑战.
研究的目的:
- 在住院患者中评估VRE和VVE殖民的流行率.
- 研究VRE/VVE菌株的遗传多样性和传播.
主要方法:
- 在160名住院患者中进行点患病率调查.
- 使用分子测定和培养的直肠拭子分析.
- 全基因组测序 (WGS) 和cgMLST用于遗传多样性.
主要成果:
- 33.7%的样本检测出vanA/vanB基因呈阳性.
- 发现了VRE (74.5%) 和VVE (25.5%),主要是E. faecium.
- 发现了7个E. faecium集群,其中ST80是最常见的;观察到传播.
结论:
- VRE和VVE菌株具有显著的毒性和耐药性.
- 由于潜在的低检测,需要仔细监测VVE.
- 有效的感染控制和分子监测对于预防至关重要.
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