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在斑马鱼 (Danio rerio) 胚胎上的哈洛佩里多尔的发育毒性

Maximos Leonardos^1,2, Charis Georgalis¹, Georgia Sergiou¹

¹Laboratory of Zoology, Biological Applications and Technology Department, University of Ioannina, 45110 Ioannina, Greece.

|August 28, 2025

概括

一种抗精神病药物, 导致斑马鱼胚胎的发育形和行为变化. 这项研究揭示了其对水生生物的毒性和剂量依赖性影响.

科学领域:

发展性毒理学
水生毒理学
药理学

背景情况:

这是一种典型的抗精神病药物.
它用于治疗各种精神疾病,包括精神病,兴奋和妄想.

研究的目的:

通过使用斑马鱼胚胎作为模型来研究利的毒性.
确定哈洛佩里多尔对正在发育的斑马鱼的致命剂量和次致命效应.

主要方法:

斑马鱼胚胎暴露在不同度 (0. 5至6. 0毫克/升) 的范围内.
估计了致命剂量 (LD50).
评估了对形态,心率,血液流动,身体长度和眼睛表面积的影响.

主要成果:

估计的致命度为1. 941毫克/升.
致死后剂量诱导剂量依赖性形,包括异常体位,黄囊胀和骨形.
哈洛佩里多尔显著影响了心率,血流,身体长度和眼睛发育,并改变了行为反应.

结论:

在斑马鱼胚胎中呈现显著的剂量依赖性毒性.
这种药物会干扰胚胎正常发育,心血管功能和行为.
斑马鱼胚胎作为评估抗精神病药物的发育毒性的一个有价值的模型.

关键词:

抗精神病药物行为甲醇的使用有毒性斑马鱼

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