与代谢功能障碍相关的脂肪酸性肝病 (MASLD) 中的阿迪波金和肝素:当前和发展趋势
Salvatore Pezzino1,2, Stefano Puleo2, Tonia Luca2,3
1Department of Medicine and Surgery, University of Enna "Kore", 94100 Enna, Italy.
Biomedicines
|August 28, 2025
概括
本文对代谢功能障碍相关的脂肪性肝病 (MASLD) 的研究趋势进行了绘制,强调了胰岛素耐药性和肠道微生物群和炎症等新兴领域的关键主题.
科学领域:
- * 与代谢功能障碍相关的脂肪性肝病 (MASLD) 研究.
- * 脂肪素与肝脏的相互作用,脂肪素和肝素.
- 图书识别分析和科学地图绘制.
背景情况:
- * MASLD是一个重要的全球健康挑战.
- * 脂肪组织与肝脏之间的复杂相互作用是MASLD的核心.
- * 目前对MASLD的研究趋势和临床转换的理解是分散的.
研究的目的:
- 系统地绘制MASLD研究的科学格局.
- * 确定新兴的研究领域和未来的临床转化方向.
- * 分析阿迪波金- 肝素信号机制的趋势及其临床影响.
主要方法:
- *对1002个出版物的图书统计分析 (2004-2025年).
- 使用主题绘图,时间趋势评估和网络分析.
- * 评估了地理分布,机构贡献和研究发展.
主要成果:
- 美国和中国在研究成果方面处于领先地位;欧洲机构在机械学方面的发现方面表现出色.
- * 核心主题包括胰岛素耐药性,脂肪肝,代谢综合征,肥胖症和 fetuin-A.
- * 新出现的主题包括炎症,氧化应激,肠道微生物群,脂质代谢和细胞应激反应 (AMPK,ER应激).
- 研究已经转向综合模型,包括肠道微生物群和线粒体功能障碍.
- * 确定了九个主要集群:心血管-代谢链接,阿迪波金-炎症通路,肝素控制和新的治疗领域.
结论:
- 这项研究概述了MASLD研究当前的趋势和新兴领域.
- 它阐明了机理学研究与临床转化之间的联系.
- * 为这个快速发展的领域的未来研究和开发提供指导.
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