增长差异化因子15 (GDF15) 的多面性作用:从癌症缓解症到向治疗的叙述性综述
Daria Maria Filippini1,2, Donatella Romaniello2, Francesca Carosi1
1Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
Biomedicines
|August 28, 2025
概括
增长分化因子15 (GDF15) 是一个关键的瘤生物标志物,与许多固体瘤的不良预后有关. 向GDF15有望改善癌症缓解和增强免疫反应,特别是在头部和部癌症.
科学领域:
- 癌症学
- 分子生物学
- 癌症研究
背景情况:
- 增长差异化因子15 (GDF15) 是一个新兴的生物标志物和治疗瘤的目标.
- 高GDF15水平与各种固体瘤的不良预后相关,包括结肠直肠,胃,胰腺,乳腺,肺,前列腺和头癌.
- GDF15通过PI3K/ AKT,MAPK/ ERK和SMAD2/3信号影响瘤的进展,促进转移,免疫逃避和化学抵抗.
研究的目的:
- 审查关于GDF15在固体瘤中的作用的文献.
- 强调GDF15在头癌症中的特殊作用.
- 探索针对GDF15-GFRAL轴的治疗策略.
主要方法:
- 叙事文献的审查.
- 专注于固体瘤中的GDF15,特别是头部和部状细胞癌 (HNSCC).
- 对GDF15-GFRAL轴的治疗向的分析.
主要成果:
- 在HNSCC中,GDF15的过度表达与侵袭性表型,辐射抵抗性和对化疗和免疫检查点抑制剂 (ICI) 的反应不佳有关.
- 在结直肠癌,胰腺癌和前列腺癌中,GDF15有助于转移和耐药性.
- 对GDF15- GFRAL轴的治疗向显示出有前途:ponsegromab改善了可克西亚的结果,而visugromab与nivolumab在ICI耐药性瘤中增强了免疫反应.
结论:
- 需要进一步研究才能充分了解GDF15在恶性瘤中的作用.
- 精确选择GDF15向治疗的患者至关重要.
- 评估与现有癌症治疗方法的结合方法是有必要的.
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