COVID-19 感染与甲状腺癌发展之间的关联:使用 TriNetX 数据库的回顾性队列研究
Hsin-Yi Wang1,2, Yi-Ching Lin1,3, Jing-Uei Hou1
1Department of Nuclear Medicine, Taichung Veterans General Hospital, Taichung City 407219, Taiwan.
Biomedicines
|August 28, 2025
概括
冠状病毒疾病2019 (COVID-19) 与甲状腺癌风险增加有关,特别是在男性和感染后甲状腺功能障碍的人群中. 需要进一步研究以了解这种SARS-CoV-2与甲状腺癌发生的联系.
科学领域:
- 内分泌学
- 癌症学
- 传染性疾病
背景情况:
- 冠状病毒疾病2019 (COVID-19) 与包括甲状腺在内的内分泌器官功能障碍有关.
- 尽管存在炎症等潜在机制,但SARS-CoV-2在甲状腺癌发展中的确切作用仍不清楚.
- 这项研究旨在确定COVID-19感染是否增加患甲状腺癌的风险.
研究的目的:
- 调查COVID-19与新发甲状腺癌的发生率之间的联系.
- 鉴定COVID-19感染后甲状腺癌风险较高的特定患者子组.
- 探索SARS-CoV-2感染与甲状腺癌发生之间的潜在联系.
主要方法:
- 使用 TriNetX 全球联合健康研究数据库进行的回顾性队列研究.
- 诊断出COVID-19的成年患者与没有COVID-19的倾向性得分匹配的队列进行比较.
- 排除有甲状腺癌病史或COVID-19疫苗接种的患者,甲状腺癌在COVID-19后至少一年被诊断出新发病.
主要成果:
- 与非COVID-19组相比,COVID-19后组的甲状腺癌发病率显著增加.
- 在COVID-19后的男性患者中发现甲状腺癌风险增加 (HR 1. 22).
- 患有COVID-19后甲状腺功能障碍 (HR 2.14) 或甲状腺功能障碍 (HR 1.83) 的患者患甲状腺癌的风险显著增加.
结论:
- COVID-19 感染与甲状腺癌的风险增加有关.
- 男性患者和患有甲状腺功能障碍的人在COVID-19后的风险特别高.
- 这些发现表明SARS-CoV-2在甲状腺癌发生过程中的潜在作用,需要进一步调查.
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