孕产妇的炎症状态对胎儿端粒长度的影响
Mircea Diaconu1,2, Flavius Olaru1, Ahmed Abu-Awwad3,4
1Department of Obstetrics and Gynecology, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Biomedicines
|August 28, 2025
概括
孕期母亲的炎症与出生时胎儿端粒长度 (FTL) 的缩短有关. 这种早期的生物衰老标记受免疫失衡的影响,特别是介质素-6 (IL-6) 与介质素-10 (IL-10) 的比率,这表明早期干预的可能性.
科学领域:
- 生殖生物学
- 免疫学
- 遗传学
背景情况:
- 胎儿端粒长度 (FTL) 是早期生物衰老和未来疾病风险的标志.
- 怀孕期间母亲的炎症对FTL的影响尚不清楚.
- 关于母体全身炎症如何影响胎儿发育和衰老标志物的证据有限.
研究的目的:
- 研究孕妇在怀孕晚期的全身炎症状态与出生时的FTL之间的关联.
- 探索特定的炎症标志物和免疫平衡在FTL确定中的作用.
- 确定与胎儿发育有关的早期预防策略的潜在目标.
主要方法:
- 对150名健康的孕妇进行前性队列研究.
- 根据hsCRP,IL-6,TNF-α和IL-10水平分成炎症和对照组.
- 使用实时PCR测量带血中的FTL,并分析与母亲的炎症标志物的关联.
主要成果:
- 炎症组表现出高hCRP,IL-6,TNF-α和较低IL-10,FTL显著缩短.
- IL-6/IL-10比率解释了28%的FTL变异,超过单个标志物.
- IL-6和hsCRP是FTL的独立负预测因子;IL-6/IL-10比率显示出最强的反相关性 (r = - 0.53).
结论:
- 在怀孕晚期的临床下母亲的炎症独立地与出生时更短的FTL有关.
- 孕产妇免疫失衡,特别是IL-6/IL-10比率,是早期生物衰老的一个可改变的决定因素.
- 怀孕期间的母亲炎症概况可能是早期预防策略的目标.
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