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疫苗接种,并发症和炎症生物标志物对COVID-19住院患者临床结果的预后影响

Sandra Bižić-Radulović1, Tijana Subotički2, Olivera Mitrović Ajtić2

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COVID-19 结果显示男性的死亡率更高. 接种疫苗可以降低COVID-19的严重程度和死亡率,但不能完全预防. 炎症生物标志物和伴随性疾病对结果的影响因性别而异.

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美国SARS-CoV-2 的变种相关疾病发生炎症性别的差异接种疫苗

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科学领域:

  • 免疫学
  • 病毒学
  • 公共卫生

背景情况:

  • 与女性相比,男性的死亡率和严重程度更高.
  • 了解疫苗接种,并发症和炎症标志物等预后因素对于住院患者至关重要.

研究的目的:

  • 通过分析性别差异,对住院COVID-19患者的临床结果比较疫苗接种,并发病和炎症生物标志物的预后影响.
  • 调查COVID-19疾病进展和治疗反应的性别特异性.

主要方法:

  • 702名住院COVID-19患者的临床和实验室参数分析 (2020年6月至2022年4月).
  • 对临床结果的基于性别的比较分析,RT-qPCR和SARS-CoV-2特异性IgM和IgG抗体水平.
  • 炎症生物标志物的评估 (CRP,IL-6,等) 肝脏酶 (AST,ALT,GGT) 的发生.

主要成果:

  • 男性的炎症前生物标志物和肝酶水平较高,与临床结果的严重程度相关.
  • 在男性中,较高的病毒载量 (较低的RT- qPCR Ct值) 与IL-6的升高相关.
  • 伴随性疾病在女性中更为频繁,结果更为严重;接种疫苗与严重性降低,炎症标志物降低和肺炎风险降低相关.
  • 疫苗接种减少了对皮质类固醇的需要,但增加了对抗病毒治疗的需要.

结论:

  • 炎症生物标志物是COVID-19严重性的关键指标,特别是在男性中.
  • 接种疫苗显著降低了COVID-19的严重程度和死亡风险,但并不能提供完整的保护.
  • 对接种疫苗的患者来说,抗炎疗法很重要,疾病进展的性别差异需要进一步研究.