无尼古丁电子烟对胃肠系统的影响:系统性审查
Ivana Jukic1,2, Ivona Matulic3, Jonatan Vukovic1,4
1Department of Internal Medicine, Division of Gastroenterology, University Hospital of Split, Spinciceva 1, 21000 Split, Croatia.
无尼古丁电子烟 (NFEC) 气溶可能会通过引起炎症和破坏肠道微生物来损害胃肠道健康. 需要更多的人类研究来证实这些临床前发现.
科学领域:
- 胃肠病学
- 毒理学
- 公共卫生
背景情况:
- 青少年和非吸烟者越来越多地使用无尼古丁电子烟 (NFEC).
- 对于NFEC对胃肠道 (GIT) 的影响尚不清楚.
研究的目的:
- 系统地审查有关NFEC对胃肠道健康和功能的现有证据.
- 综合体内,体内和人体研究的发现.
主要方法:
- 根据PRISMA指南搜索了Medline,科学网络,Cochrane和Scopus (2025年7月).
- 包括检查NFEC对任何GIT段 (口腔,肝脏,肠道,微生物组) 的研究.
- 提取和综合研究设计,暴露和结果的数据.
主要成果:
- 21项研究符合纳入标准;大多数是临床前的.
- NFEC气溶可能诱导炎症,降低细胞活力,并破坏微生物代谢.
- 动物研究表明肝氧化应激,脂质代谢发生变化,肠道屏障功能障碍和潜在的肥胖症.
结论:
- 有限的临床前证据表明NFEC可以对胃肠道健康产生负面影响.
- 强有力的人体研究对于确定临床相关性和制定政策至关重要.
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