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Methods for Controlling Microbial Growth01:29

Methods for Controlling Microbial Growth

Microbial growth control refers to various methods employed to inhibit, reduce, or eliminate microorganisms to ensure safety and hygiene across different settings. These methods are categorized based on the target environment and the level of microbial control required.Biocides are versatile agents designed to control microorganisms by either inhibiting their growth or outright killing them. These agents work through various physical, chemical, mechanical, or biological mechanisms. The...
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Gene Regulation in Microbial Communities: Quorum Sensing

Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
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Microbiota Modulation by Antibiotics

Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...

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Updated: Jun 3, 2026

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
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调节微生物组的水凝:用于感染控制的组织再生疗法

Germán Reynaldo Jiménez-Gastelum1, Carlos Esteban Villegas-Mercado2, Juan Luis Cota-Quintero1

  • 1Faculty of Biology, Autonomous University of Sinaloa, Culiacan PC 80013, Mexico.

Gels (Basel, Switzerland)
|August 28, 2025
PubMed
概括

功能化水凝可以调节微生物组以改善组织再生和控制感染. 这些先进的材料提供有益的微生物和抗微生物,促进愈合和免疫平衡,以获得更好的治疗结果.

关键词:
基于水凝的支架水凝感染控制微生物组微生物组调制组织再生

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科学领域:

  • 生物材料科学
  • 微生物学
  • 复原医学

背景情况:

  • 皮肤和肠道微生物对组织平衡,免疫调节和愈合至关重要.
  • 微生物失衡会导致再生障碍和慢性伤口等疾病的感染风险增加.

研究的目的:

  • 审查功能化水凝在治疗应用中的微生物组调节作用.
  • 探索基于水凝的益生菌,益生菌和抗菌剂用于组织再生和感染控制.

主要方法:

  • 对水凝功能化和微生物组调节的文献综述.
  • 用于输送益生菌的水凝系统的分析 (例如, *Lactobacillus plantarum*, *Prevotella histicola*).
  • 用抗菌剂功能化的水凝的检查 (例如,银纳米颗粒,氧化捐赠剂,细菌素).

主要成果:

  • 水凝增强了有益细菌的活力和向传递,促进了免疫耐受性.
  • 功能化水凝有效地破坏生物膜和清除病原体.
  • 这些系统促进了亲再生性免疫反应,包括M2巨分化和调节性T细胞诱导.

结论:

  • 功能化水凝为基于微生物的疗法提供了多功能平台,用于组织再生和感染管理.
  • 像3D生物打印和响应材料这样的先进水凝技术提高了临床适用性.