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Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Updated: Sep 10, 2025

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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使用湿颗粒法开发含有黄素的氨酸纳米凝配方,以提高溶解和稳定性

Natkhanang Mookkie Boonpetcharat1, May Thu Thu Kyaw1, Veerakiet Boonkanokwong1

  • 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Phyathai Road, Bangkok 10330, Thailand.

Gels (Basel, Switzerland)
|August 28, 2025
PubMed
概括

这项研究开发了新型颗粒配方,使用聚-N-异烯胺 (HA-g-pNIPAM) 植入的氨酸来改善黄素.

关键词:
黄素交付系统氨酸衍生物通过口服

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科学领域:

  • 制药科学
  • 材料科学

背景情况:

  • 黄素具有显著的抗氧化,抗炎和抗瘤特性.
  • 由于可溶性不佳,不稳定性和快速降解,库尔库的治疗用量有限.

研究的目的:

  • 使用多-异烯胺 (HA-g-pNIPAM) 移植氨酸 (HA-g-pNIPAM) 配方来增强氨酸的溶解和稳定性.
  • 开发和描述可改善黄素的颗粒配方.

主要方法:

  • 制备了三个配方:物理混合物 (F10),封装 (F10 Encap) 和对照颗粒 (F11).
  • 评估了稳定性,流动性,颗粒大小分布和药物释放特征.
  • 在特定的温度和湿度条件下,对黄素含量进行了30天的评估.

主要成果:

  • 在30天后,F10 Encap表现出优异的黄素稳定性,与F11 (~70%) 相比,黄素含量保持在~94%.
  • 所有配方均表现出优异的流动性和一致的颗粒大小分布 (150~180μm).
  • 观察到F10 Encap和F10在240分钟内持续释放黄素,这表明释放是受控的.

结论:

  • HA- g- pNIPAM显著改善了黄素的溶解和稳定性.
  • 在HA-g-pNIPAM中封装是一种有前途的策略,可以提高黄素的口服生物可用性和治疗潜力.