用于皮肤莱什曼病的局部梅格林抗凝:配方,评估和洞察
Lilian Sosa1,2, Lupe Carolina Espinoza3,4, Alba Pujol5
1Instituto de Investigaciones en Microbiología (IIM), Facultad de Ciencias, Universidad Nacional Autónoma de Honduras (UNAH), Tegucigalpa 11101, Honduras.
Gels (Basel, Switzerland)
|August 28, 2025
概括
一种新型的美胺抗凝 (MA- 凝) 已开发用于皮肤莱什曼病. 这种局部凝显示出有前途的物理化学,安全性和抗寄生虫特性,
科学领域:
- 制药科学
- 寄生虫学
- 皮肤病学
背景情况:
- 莱什曼病是热带和亚热带地区普遍存在的传染病.
- 皮肤莱什曼病是一个重大的全球健康挑战.
- 对于局部化的莱什曼病,人们寻求局部治疗.
研究的目的:
- 开发和描述用于皮肤莱什曼病治疗的局部胺抗凝 (MA-凝).
- 评估MA凝的物理化学,生物制药,安全性和抗寄生素特性.
- 通过in silico研究探索胺的潜在作用机制.
主要方法:
- 使用美胺抗酸 (MA) 和Pluronic F127制备的MA凝.
- 描述包括形态 (SEM),pH,胀,多孔性,质和热分析 (DSC).
- 在体外药物释放和体外皮肤透中涉及的生物制药评估. 通过皮肤生物力学和细胞毒性评估安全性. 针对Leishmania infantum促生虫和促生虫的抗寄生虫活性进行测试. 进行了接研究.
主要成果:
- 这种MA凝具有海绵状的多孔结构,pH值为5. 45,胀迅速,多孔度为85. 07%.
- 不同扫描热量计证实MA和Pluronic F127之间没有不兼容性.
- 观察到第一阶级药物释放动力学,在皮肤中显著保留药物 (22. 11μg/ g/ cm2) 并且没有受体透.
- 凝没有细胞毒性,皮肤损伤或微生物污染.
- 强烈的虫杀伤性活性得到证实,IC50值为3. 56微克/毫升 (虫) 和23. 11微克/毫升 (虫).
- 在分析中,MA针对三个潜在的治疗途径.
结论:
- 开发的MA凝具有有利的局部输送的物理化学和生物制药特性.
- 该配方可安全应用于皮肤,并且具有显著的体外和体外抗寄生素活性.
- MA- 凝具有作为皮肤莱什曼病的有效局部治疗剂的潜力.
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