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Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...
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局部精油载微乳液的配方,优化和综合性特征

Adeola Tawakalitu Kola-Mustapha1, Muhabat Adeola Raji2, Yusra Abdulkarim Alzahrani1

  • 1Department of Pharmaceutical Sciences, College of Pharmacy, Alfaisal University, Riyadh 11533, Saudi Arabia.

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概括
此摘要是机器生成的。

稳定的精油微乳液对治疗Cutibacterium acnes具有前景,为合成药物提供了潜在的替代品,并解决了治疗中的抗菌素耐药性问题.

关键词:
常见的精油的使用微乳当前情况

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科学领域:

  • 制药科学
  • 皮肤病学
  • 微生物学

背景情况:

  • (AV) 是一种常见的炎症性皮肤疾病,与Cutibacterium有关.
  • 目前针对AV的局部治疗可能会引起副作用,并面临抗菌素耐药性 (AMR) 的挑战.
  • 精油 (EOs) 具有针对C. acnes的潜在抗菌特性.

研究的目的:

  • 开发和描述稳定的局部含有精油的微乳液.
  • 评估这些微乳剂对C. acnes的体外抗菌活性.
  • 为使用EO作为AMR易受合成药物治疗提供科学依据.

主要方法:

  • 确定了菌,茶树和草的最低抑制度 (MIC).
  • 使用微乳液和碳醇/酸凝混合物 (1:1比) 制备的含有EO的微乳液.
  • 对物理性质 (外观,气味,pH,均性,扩散性,粘度) 进行了特征分析,并在不同温度下对三个月的稳定性进行了评估.

主要成果:

  • 对菌,茶树和草的MIC分别为0. 08%,0. 16%和0. 62%.
  • 开发的微乳液是白色的,光滑的,具有特征性的EO气味,并表现出适当的pH (4.81-5.00),可扩散性 (9.79-12.76 cm2) 和粘度 (29,500-31,130 cP).
  • 在4°C,25°C和40°C的温度下,微乳液在三个月的时间内表现出良好的稳定性.

结论:

  • 已成功开发出含有精油的稳定微乳液,用于潜在的Cutibacterium.
  • 这些配方对药物开发具有有前途的特征,可以作为传统治疗的替代品.
  • 这些微乳液代表了在治疗中抗菌药物耐药性的潜在进展.