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含有Rb1的比格尔的制造,特征和体外消化行为

Yang Luo¹, Gao Xiong¹, Xiao Gong²

¹College of Notoginseng Medicine and Pharmacy, Wenshan University, Wenshan 663099, China.

Gels (Basel, Switzerland)

|August 28, 2025

概括

这项研究开发了一种食品级大豆制剂,以提高Rb1的口服生物可用性. 它保护Rb1免受降解,并确保在肠道中持续释放.

科学领域:

食品科学与技术
材料科学
药理学

背景情况:

诺托金化物Rb1 (Rb1) 具有显著的健康益处,但由于胃降解和肠道透性低,其口服生物利用性较差.
开发有效的输送系统对于利用Rb1治疗潜力至关重要.

研究的目的:

为封装Rb1开发和优化一款食品级大饼系统.
增强Rb1的稳定性,控制其释放,并提高其口服生物可用性.

主要方法:

使用单甘油和大豆油制成的油凝.
制备Rb1载荷的二进制水凝与凝和香.
在Tween-80中化水凝以制造大豆.
优化水凝与油凝的比例.
使用风学,共聚焦显微镜和差分扫描热量计 (DSC) 进行表征.
在体外消化试验以评估酸性保护和释放特征.

主要成果:

鉴定出一种具有优越的结构完整性 (峰值G' = 290.64 Pa) 的最佳大制剂 (水凝与油凝的比率为 4: 6).
在水凝阶段实现了高封装效率 (99. 91%) 和均的Rb1分布.
巨型体显示了热缓冲能力 (在55°C时的内热过渡),并保留了水和油.
证实了有效的防治胃部降解 (Rb1释放率< 5%) 和持续的肠道释放率 (> 90% 在4小时内).

结论:

开发的食品级大系统有效地保护Notoginsenoside Rb1免受胃部的降解.
这种系统可使Rb1在肠道中得到控制和持续释放,显著增强其口服输送潜力.
该系统的可调节的气质,热稳定性和食品级成分使其非常适合用于功能性食品和营养药品.

关键词:

大型系统标志性封装方式在体外消化基因化物 Rb1 油混合动力

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