在完全接种疫苗和未接种疫苗的人群中,具有严重COVID-19的TMEM173/STING1基因变异的关联
Daniel Vázquez-Coto1, Marta García-Clemente2,3,4, Guillermo M Albaiceta4,5,6,7,8
1Genética Molecular, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain.
Life (Basel, Switzerland)
|August 28, 2025
概括
常见的STING1基因变异与接种疫苗的人群中严重的COVID-19有关. 这一发现表明,尽管接种了疫苗,但仍存在严重疾病的潜在遗传倾向,强调了STING途径在免疫反应中的作用.
科学领域:
- 免疫学
- 遗传学
- 病毒学
背景情况:
- 通过cGAMP激活的STING (干扰基因刺激剂) 蛋白对抗感染的先天免疫力至关重要.
- 慢性STING通路过度激活与各种疾病有关,包括在严重的COVID-19中出现的超炎性细胞因子风暴.
- STING调节对抗病毒反应和疫苗有效性都很重要,抗原剂增强了对SARS-CoV-2的抗体标位.
研究的目的:
- 调查常见的功能性STING1/TMEM173基因多态和严重的COVID-19之间的关联.
- 在未接种疫苗的患者,接种疫苗的患者和对照人群中比较这些多态度的频率.
主要方法:
- 801名未接种疫苗的患者,105名完全接种mRNA疫苗的患者和300名对照人群的STING1多态 rs78233829和rs1131769的基因定型.
- 研究组之间的变异频率的统计比较.
- 对STING1变体的链接不平衡和哈普类型频率的分析.
主要成果:
- 在未接种疫苗的患者和对照人群之间没有观察到STING1变异的显著差异.
- 与未接种疫苗的患者相比,接种疫苗的患者表现出rs78233829 C等位基因 (STING1 230Gly) 的频率明显高 (p=0. 003).
- 在接种疫苗的个体中,STING1变异存在强烈的链接不平衡,保护性单元类型更为常见. LTZFL1 rs67959919的多态性与严重的COVID-19有关,但在接种疫苗和未接种疫苗的群体之间没有差异.
结论:
- 在完全接种疫苗的患者中,常见的功能性STING1多态性与严重的COVID-19风险的增加显著相关.
- 这些发现强调了宿主基因,STING通路激活和COVID-19严重程度之间的复杂相互作用,即使是接种疫苗后.
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