唐氏综合征患者的甲状腺功能低下和抑郁症之间的关联:回顾性分析
Gregory Sabel1, Alishah Ahmadi1, Dhruba Podder1
1School of Medicine, New York Medical College, Valhalla, NY 10595, USA.
Life (Basel, Switzerland)
|August 28, 2025
概括
患有唐氏综合征的人患甲状腺功能低下的几率更高. 伴随性甲状腺功能低下症与DS患者的抑郁风险增加有关,这强调了甲状腺查的必要性.
科学领域:
- 遗传学和内分泌学
- 精神病学和行为科学
背景情况:
- 唐氏综合症是一种遗传性疾病,与智力障碍和伴随疾病的风险增加有关.
- 甲状腺功能障碍和精神健康障碍,特别是抑郁症,在DS患者中很常见.
- 甲状腺功能低下和抑郁症之间的联系需要进一步研究.
研究的目的:
- 在唐氏综合征患者中研究甲状腺功能低下和抑郁症之间的相关关系.
- 确定伴随性甲状腺功能低下是否与DS患者的抑郁率较高有关.
主要方法:
- 2016-2019年国家住院样本 (NIS) 数据集的回顾性分析.
- 根据ICD-10代码,包括患有唐氏综合征,甲状腺功能低下和抑郁症的患者.
- 对人口因素进行调整的调查加权线性回归分析.
主要成果:
- 与普通人群 (10. 28%) 相比,患有多发性甲状腺炎的个体的患病率明显高 (29. 88%).
- 患有甲状腺功能低下症的患者患有抑郁症的患病率高于没有甲状腺功能低下症的患者 (8. 67%).
- 抑郁症的总体患病率 (4. 69%) 低于一般人群 (12. 27%).
结论:
- 甲状腺功能低下是唐氏综合征患者抑郁症的重要潜在原因.
- 进一步的研究对于阐明甲状腺功能障碍的机制和开发查/治疗策略至关重要.
- 对甲状腺健康的临床关注对于管理DS患者的精神病相关疾病至关重要.
更多相关视频
06:38In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells
Published on: March 7, 2025
619
06:55An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
Published on: December 2, 2015
22.7K
相关概念视频
Depression: Overview
331
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
331
Depressive Disorders: MDD and Dysthymia
208
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
208
Depressive Disorders: Etiology
165
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
165
Meiosis vs. Mitosis
58.1K
Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
58.1K
Long-term Depression
31.4K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
31.4K
Synthesis and Regulation of Thyroid Hormones
5.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
5.1K
