破坏防御:双A及其类似物对人体体外抗体产生的影响
Francesca Carlotta Passoni1, Martina Iulini1, Valentina Galbiati1
1Laboratory of Toxicology and Risk Assessment, Department of Pharmacological and Biomolecular Sciences "Rodolfo Paoletti", Università degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy.
Life (Basel, Switzerland)
|August 28, 2025
概括
双A (BPA) 和它的类似物可以抑制免疫反应,特别是抗体的产生. 这项研究发现BPA类似物并不比BPA更安全,这表明潜在的免疫毒性风险.
科学领域:
- 免疫毒理学
- 内分泌学
背景情况:
- 双A (BPA) 是一种已知会损害免疫功能的内分泌干扰化学物质.
- BPA具有类似雌激素的活性,可以起到促炎作用,影响免疫反应的有效性.
- 由于担心BPA的免疫毒性,因此在欧洲禁止将其用于与食品接触的材料,并引入类似物.
研究的目的:
- 评估BPA和六种类型的免疫毒性:BPAP,BPE,BPP,BPS-MAE,BPZ和TCBPA.
- 评估这些化合物的体外对抗体产生的影响.
- 确定免疫毒性影响的潜在性别差异.
主要方法:
- 从健康的男性和女性捐赠者获得的外周血液单核细胞 (PBMC) 暴露于BPA及其类型的度上升24小时.
- 用 rhIL-2 和 ODN2006 刺激细胞.
- 在第六天测量IgM和IgG分泌,以评估抗体的产生.
主要成果:
- 所有测试的化合物都以度依赖的方式抑制了抗体的产生.
- 观察到与性别相关的免疫毒性作用的显著差异.
- 双P (BPP) 作为抗体生成抑制剂表现最强,而双E (BPE) 则表现最弱.
结论:
- 结果不支持BPA类似物在免疫毒性方面比BPA更安全.
- BPA及其类似物对免疫功能,特别是抗体产生存在潜在风险.
- 需要进一步研究以了解BPA类型的长期免疫毒理学影响.
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