怀孕期间母亲的生活方式及其对子女端粒长度的影响
Elena Vakonaki1, Maria Theodora Vitiadou1, Eleftherios Panteris2
1Laboratory of Toxicology, School of Medicine, University of Crete, 70013 Heraklion, Greece.
Life (Basel, Switzerland)
|August 28, 2025
概括
怀孕期间母亲的生活方式显著影响胎儿的端粒长度 (TL). 良好的营养和运动等健康习惯可以延长寿命,而不良习惯可能会缩短寿命,影响长期健康.
科学领域:
- 遗传学和表观遗传学
- 产妇和胎儿医学
- 基因组稳定性
背景情况:
- 端粒 (TL) 是保护染色体末端的DNA序列,对基因组稳定性至关重要.
- 胎儿端粒长度 (TL) 是长期健康和疾病风险的生物标志物.
- 怀孕期间母亲的健康越来越多地被认为对胎儿发育有影响.
研究的目的:
- 审查孕期母亲生活方式因素对胎儿端粒长度的影响.
- 确定与胎儿TL积极或负面影响相关的特定母亲行为和暴露.
- 突出胎儿TL对后代未来健康结果的影响.
主要方法:
- 这项研究是对现有科学文献的叙述性审查.
- 它综合了母亲的生活方式因素及其与胎儿端粒长度 (TL) 的相关性.
- 这篇评论考察了怀孕期间的各种营养,环境和行为影响.
主要成果:
- 发现胎儿TL和母亲摄入维生素C,D,叶酸,,地中海饮食和体育活动之间的积极关联.
- 观察到与母亲高碳水化合物/脂肪饮食,酒精消耗,三素暴露和睡眠呼吸障碍的负相关性.
- 有不一致的证据表明,母亲的压力,吸烟,咖啡因,肥胖和睡眠质量会影响胎儿的睡眠时间.
结论:
- 孕妇在怀孕期间的生活方式的选择极大地影响胎儿的端粒长度 (TL),影响基因组完整性.
- 优化母亲的营养,饮食和体育活动可以促进胎儿的寿命延长,并促进长期健康.
- 需要进一步研究以了解这些影响的精确机制和时间,以便针对性地进行产前干预.
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