染色体结构重组对PGT-SR周期试验室结果的影响:基于倾向性得分的研究
Daria Marzanati1,2, Sara D'Alessandro3, Davide Gentilini1,4
1Department of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, Italy.
Life (Basel, Switzerland)
|August 28, 2025
概括
接受结构重组 (PGT-SR) 预植入基因检测的患者在活检时的囊数量较少. 相互转移显著降低了正常/平衡囊的发生率,影响了治疗的成功.
科学领域:
- 生殖医学
- 人类遗传学
- 辅助生殖技术
背景情况:
- 染色体结构重组 (SR) 可能导致胚胎失衡.
- 辅助生殖技术 (ARTs) 与植入前结构重组遗传检测 (PGT-SR) 可以识别染色体正常/平衡的胚胎.
- 关于PGT-SR的试管婴儿实验室结果的数据有限.
研究的目的:
- 为了比较PGT-SR和PGT-A周期之间的试管婴儿实验室结果.
- 在PGT-SR周期中研究影响正常/平衡胚胎细胞数量的因素.
主要方法:
- 548个ART周期 (129个PGT-SR,419个PGT-A) 的回顾性队列研究.
- 倾向性得分匹配和后勤回归用于结果比较.
- 评估SR类型和携带者性别影响的通用线性混合效应模型.
主要成果:
- 在PGT-SR和PGT-A组中,受精率相似.
- 在PGT-SR循环中,胚胎细胞发育率显著降低 (36. 7% vs 47. 1%),胚胎细胞发育率高 (9. 6% vs 21. 1%).
- 非互惠的SR产生了比互惠转位更高的正常/平衡胚胎细胞率 (89. 9%).
结论:
- 接受PGT-SR治疗的患者产生较少的细胞囊.
- 相互转移显著降低了正常/平衡胚胎细胞的可用性.
- 在PGT-SR病例中,个性化咨询对于管理患者的期望和临床决策至关重要.
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