两者之间的相关性 胃组织病理学和NAFLD:一项回顾性观察研究
Ioana Alexandra Cardos1, Cătălina Dănilă1, Ovidiu Laurean Pop1
1Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania.
Life (Basel, Switzerland)
|August 28, 2025
概括
杆菌感染与非酒精性脂肪性肝病 (NAFLD) 纤维化得分较高有关,特别是BARD和APRI指数. 这表明NAFLD患者的肝病严重程度与H. pylori之间存在相关性.
科学领域:
- 肝病学
- 胃肠病学
- 传染性疾病
背景情况:
- 之前的研究表明,Helicobacter pylori (H. pylori) 感染在非酒精性脂肪肝 (NAFLD),肝纤维化,肝硬化,胰岛素耐药性和非酒精性脂肪肝 (NASH) 中的作用.
- 需要进一步研究H. pylori与肝病的进展之间的关联,特别是在非侵入性纤维化标志物方面.
研究的目的:
- 通过非侵入性评分系统,评估患有或没有H. pylori感染的患者的肝纤维化风险.
- 评估纤维化严重程度得分与胃部组织病理学发现之间的相关性.
- 在肝纤维化患者中确定前瘤胃病变的风险.
主要方法:
- 进行了一项涉及110名患者的研究 (65名H. pylori阳性,45名H.
- 使用曼- 惠特尼测试计算和比较不同组的非侵入性纤维化得分 (APRI,BARD,FIB-4).
- 用多重线性回归分析来确定与年龄和H. pylori状态的关联. 还进行了细胞病理学检查.
主要成果:
- 与 H. pylori 阴性患者相比,NAFLD 的 H. pylori 阳性患者的 BARD 评分和 APRI 指数显著提高.
- 在H. pylori阳性个体中,FIB-4指数的增加是微不足道的.
- BARD评分和APRI指数与年龄和H.
结论:
- 在NAFLD和胃炎患者中,H. pylori感染与肝纤维化得分升高有很大相关性.
- 这些发现表明H. pylori感染的复杂性与肝病的胃组织学的复杂性之间存在联系.
- 像BARD和APRI这样的非侵入性评分可能对评估NAFLD患者的纤维化风险有价值.
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