多器官参与,特别是长期COVID中的肝损伤:叙述性审查
Carmen-Elena Florea1,2,3, Bianca Bălaș-Maftei1,2,3, Alexandra Rotaru1,2
1Doctoral School, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Life (Basel, Switzerland)
|August 28, 2025
概括
长期的COVID可以通过各种机制造成持续性肝损伤,包括直接的病毒影响和炎症. 对于在SARS-CoV-2感染后出现肝脏问题的患者,持续监测至关重要.
科学领域:
- 肝病学
- 传染性疾病
- 免疫学
背景情况:
- COVID-19 大流行导致长期COVID,其特征是持续影响多个器官的症状.
- 在SARS-CoV-2感染后,肝脏被确定为持续损伤的重要部位.
- 轻微的COVID-19病例也可能导致疲劳和认知障碍等长期后果.
研究的目的:
- 审查COVID-19后器官参与的当前知识.
- 专注于与SARS-CoV-2感染相关的肝脏表现和危险因素.
- 讨论与常见的炎症和血栓性途径有关的神经,心血管和其他后果.
主要方法:
- 对有关COVID-19和器官参与的现有文献进行叙述性审查.
- 对肝损伤的致病,临床表现和风险因素的综合信息.
- 检查COVID后的常见炎症和血栓性途径.
主要成果:
- COVID-19 后的肝损伤是多因素的,涉及直接的病毒作用,免疫反应,微血管损伤和药物毒性.
- 肝脏表现范围从转氨酶升高到胆血管病变和纤维化,持续数月.
- 危险因素包括代谢障碍,肥胖和先前存在的肝炎,需要专门的护理.
结论:
- 由于肝脏的代谢和炎症作用,肝脏功能障碍是长期COVID的一个关键问题.
- 长期监测和跨学科护理对于COVID后肝脏问题患者至关重要.
- 需要对器官特异性和系统性相互作用进行进一步的研究,以完善管理策略.
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