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Updated: Sep 10, 2025

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9
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Published on: August 28, 2018

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新型小分子GRP94调节器增加PCSK9分泌并促进LDLR降解

Wenjing Yan1, Yongwang Zhong1, Shengyun Fang1,2

  • 1Department of Pharmacology and Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Life (Basel, Switzerland)
|August 28, 2025
PubMed
概括

一种名为NSC637153 (cp153) 的新化合物有选择性地向内质网膜护理器GRP94. 这一发现为研究蛋白质平衡和开发与GRP94功能障碍相关的疾病治疗提供了一个工具.

关键词:
与ER相关的降解 (ERAD)在 GRP94在PCSK9-LDLR蛋白质质量控制

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