通过LOU/C/Jall和Sprague-Dawley老鼠诱导的MI-RAT©骨关节炎模型,比较疼痛表达及其与肠道微生物群的联系
Marilyn Frézier1, Colombe Otis1, Emilie Labelle1
1Groupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, St.-Hyacinthe, QC J2S 2M2, Canada.
International journal of molecular sciences
|August 28, 2025
概括
大鼠的健康衰老与特定的肠道细菌有关, 这项研究探讨了肠-大脑轴
科学领域:
- 神经科学
- 胃肠病学
- 老年学
- 疼痛研究
背景情况:
- 肠-大脑轴在生理过程中起着至关重要的作用,
- 老龄化与肠道微生物群和疼痛敏感性的变化有关.
- 了解这些相互作用对于治疗老年人的慢性疼痛至关重要.
研究的目的:
- 研究肠-脑轴在老年肌肉骨慢性疼痛中的作用.
- 为了比较两种老老鼠的关节炎疼痛,认知功能和肠道微生物群.
- 探索肠道微生物组成与疼痛控制机制之间的关系.
主要方法:
- 在Sprague-Dawley (SD) 和LOU/C/Jall (LOU) 老鼠中使用了手术诱导的骨关节炎 (OA) 模型.
- 在60天内通过定量感官测试 (机械敏感,抑制控制) 评估OA疼痛反应.
- 分析了空间记忆,肠道微生物组成,关节结构变化和脊髓神经.
主要成果:
- 与OA诱导后的SD大鼠相比,LOU大鼠表现出更高的机械过敏性和内源抑制控制.
- 这两种菌株的认知功能,关节变化和脊髓神经的表达是可比的.
- 在LOU (例如,Akkermansia spp.) 之间观察到肠道微生物组成的显著差异. 和SD (例如,乳杆菌 spp.) 它们是老鼠.
结论:
- 健康的衰老可能与更有效的内源性疼痛控制和独特的肠道细菌特征有关.
- 特定的肠道细菌与老鼠的疼痛控制机制相关.
- 这项研究强调了肠道微生物群在与衰老相关的慢性疼痛管理中的潜在影响.
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