相关实验视频

Updated: Sep 10, 2025

Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

桃花与橄花粉之间的关联非特异性脂质转移蛋白质过敏和HLAII类表型

Paula Álvarez^1,2, Juan Molina^1,2,3, Raquel Bernardo^1,2

¹Department of Immunology and Allergy, Reina Sofía University Hospital, 14004 Córdoba, Spain.

International journal of molecular sciences

|August 28, 2025

概括

人类白细胞抗原 (HLA) 变异会影响对非特异性脂质转移蛋白 (nsLTP) 的过敏. 像DRB1*11和DRB1*04这样的特定HLA基因与敏感性有关,而DQB1*05可能会提供对nsLTP过敏的保护.

科学领域:

免疫学
遗传学
过敏学

背景情况:

对橄花粉 (Ole e 7) 和桃子 (Pru p 3) 非特异性脂质转移蛋白 (nsLTP) 的同敏感性在西班牙南部普遍存在.
人类白细胞抗原 (HLA) 类II等位基因在nsLTP敏感化中的作用尚不完全理解.

研究的目的:

研究特定的HLAII类等位基因与对Ole e7和Pru p3的敏感性之间的关联.
探索HLA-nsLTP表皮质结合亲缘关系在过敏发展中的潜在作用.

主要方法:

在单重敏感 (Ole e7或Pru p3) 和双重敏感的患者中对HLAII类等位基因的基因定型.
使用免疫表皮基数据库 (IEDB) 来预测 nsLTP 的T细胞表皮基.
分析HLA-表皮质结合 afinity,以评估呈现潜力.

主要成果:

在Pru p3单重敏感患者中观察到HLA-DRB1*11和DQB1*03的频率增加.
在Ole e 7单一敏感的患者中发现HLA-DRB1*04的频率更高.
预测Pru p3表位对DRB1*11和Ole e7表位对DRB1*04具有很高的结合亲和力,这表明表现优越. 较低的DQB1*05频率和较低的结合亲和力表明它具有保护作用.

结论:

特定的HLAII类等位基因,特别是DRB1*11和DRB1*04,与nsLTP敏感性有显著的关联.
在确定个体对nsLTP过敏的敏感性方面,HLA与表皮质的结合关系可能起着至关重要的作用.
HLA-DQB1*05可能起到对nsLTP敏感性的保护作用.

关键词:

HLA 抗原过敏的原因检测p 3 过敏原 T细胞表位非特异性脂质转移蛋白

更多相关视频

Antigenic Liposomes for Generation of Disease-specific Antibodies

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis

Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis

Published on: October 15, 2021

相关概念视频

Cross-reactivity

Cross-reactivity

Allergic Reactions

Allergic Reactions

Hypersensitivities

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...

Antigens Involved in Adaptive Immunity

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...

Test Cross

Test Cross

Alleles are different forms of the same gene. Humans and other diploid organisms inherit two alleles of every gene, one from each parent.

Allergic Drug Reactions

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...