纤维细胞激活蛋白 (FAP) 作为纤维卵巢衰老的血清生物标志物:基于转化转录组目标的临床验证研究
Hyun Joo Lee1, Yunju Jo2, Shibo Wei2
1Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Pusan National University Hospital Biomedical Research Institute, Busan 49241, Republic of Korea.
International journal of molecular sciences
|August 28, 2025
概括
纤维细胞激活蛋白 (FAP) 是一种新的卵巢衰老血清生物标志物. 它反映了卵巢肌瘤的纤维化变化,为生殖风险评估提供了超越传统荷尔蒙标记的见解.
科学领域:
- 生殖生物学
- 生物标志物的发现
- 卵巢衰老研究
背景情况:
- 年龄是不充分的生殖能力指标.
- 卵巢衰老涉及卵巢的纤维化重塑,目前无法通过临床工具进行评估.
研究的目的:
- 识别和验证一种用于纤维化卵巢衰老的新血清生物标志物.
- 将机器学习应用于人类卵巢转录基因数据以识别生物标志物.
主要方法:
- 监督机器学习应用于GTEx转录组数据以识别候选基因.
- 在患者队伍中对纤维细胞激活蛋白 (FAP) 和集合因-11 (COLEC11) 的临床验证.
- 对卵巢储备标志物 (例如AMH) 和荷尔蒙指数进行血清FAP/COLEC11水平的分析.
主要成果:
- 血清FAP水平与抗Müllerian激素 (AMH) 相反相关 (r = - 0.61, p = 0.001),特别是在卵巢储备减少的妇女中.
- FAP水平与年龄和中央荷尔蒙调节无关,这表明结构特异性.
- COLEC11与年龄相关,但没有区分DOR状态.
结论:
- 循环FAP是独立于年龄的卵巢纤维老化的有效生物标志物.
- FAP提供了传统激素标记物无法捕获的结构特异信息.
- FAP具有改善生殖风险评估和了解卵巢衰老病理生理学的潜力.
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