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研究领域生物医学和临床科学瘤学和致癌症预测和预后标志物
在PitNET中PD-L1,Ki-67,P53和Cyclin D1的作用:74例患者的诊断和预后影响

在PitNET中PD-L1,Ki-67,P53和Cyclin D1的作用:74例患者的诊断和预后影响

Anna Krzentowska ¹, Beata Biesaga ², Ryszard Czepko ³, Anna Merklinger-Gruchała ², Dariusz Adamek ⁴, Małgorzata Jasińska ⁵, Barbara Pluta ⁶, Wiktoria Michalska ⁶, Katarzyna Wróblewska ⁶, Filip Janczy ⁶, Filip Gołkowski ¹

Anna Krzentowska ¹, Beata Biesaga ², Ryszard Czepko ³

¹Department of Endocrinology and Internal Medicine, Medical College, Andrzej Frycz Modrzewski Krakow University, 30-705 Kraków, Poland.
²Faculty of Health Sciences, Medical College, Andrzej Frycz Modrzewski Krakow University, 30-705 Kraków, Poland.
³Department of Neurosurgery, Medical College, Andrzej Frycz Modrzewski Krakow University, 30-705 Kraków, Poland.
⁴Department of Neuropathology, and Chair and Department of Pathomorphology, Faculty of Medicine, Jagiellonian University Medical College, 31-008 Kraków, Poland.
⁵Department of Histology, Jagiellonian University Medical College, 31-008 Kraków, Poland.
⁶Students' Scientific Interest Group, Medical College, Andrzej Frycz Modrzewski Krakow University, 30-705 Kraków, Poland.

⁰Department of Endocrinology and Internal Medicine, Medical College, Andrzej Frycz Modrzewski Krakow University, 30-705 Kraków, Poland.

International Journal of Molecular Sciences +

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2025年八月28日

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在PubMed上查看摘要

概括

此摘要是机器生成的。

在垂体神经内分泌瘤 (PitNETs) 中研究了编程死亡配体1 (PD-L1) 和Ki-67等增殖生物标志物. PD-L1表达可能有助于识别侵袭性无细胞腺瘤并表明侵袭性.

科学领域

内分泌学
癌症学
病理学

背景情况

垂体神经内分泌瘤 (PitNETs) 是罕见的,通常是良性的,但侵入性和静音的亚型会带来挑战.
目前的世卫组织分类依赖于转录因素,但影响PitNET行为的因素正在调查中.

研究的目的

在PitNET中评估编程死亡配体1 (PD-L1) 和增殖生物标志物 (Ki-67,cyclin D1,P53).
将生物标志物表达与转录因子和PitNET亚型相关联.
确定与瘤侵入性相关的因素.

主要方法

在74个PitNET组织样本中使用免疫组织化学分析PD- L1,Ki-67,P53和环素D1的表达.
生物标志物表达水平被量化并与瘤特征相关.
进行统计分析以评估与年龄和侵袭性的关联.

主要成果

在各种PitNET亚型中观察到PD- L1表达 (≥1%),包括淋巴细胞和无细胞腺瘤.
较高的Ki-67表达 (≥3%) 与患者年龄较小有关 (p=0. 03).
较高的cyclin D1 (≥10%) 和较低的P53 (<10%) 的组合预测了侵入性 (哈迪度量表). 在PD- L1中,侵袭性概率最高 (aOR=2. 35).

结论

在特定的PitNET类型中存在PD-L1表达,可能有助于识别无细胞腺瘤.
结合的D1和P53水平可以表明瘤的侵入性.
PD-L1显示为预测PitNET行为的生物标志物.

关键词:

环素D1 其他: P53 其他其他类型问题解决方案生物标志物侵袭性转录因子

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