益生菌对胃肠癌的分子作用机制
Christina Thoda1, Maria Touraki1
1Laboratory of General Microbiology, Department of Genetics, Development and Molecular Biology, School of Biology, Faculty of Sciences, Aristotle University of Thessaloniki (A.U.TH.), 54 124 Thessaloniki, Greece.
International journal of molecular sciences
|August 28, 2025
概括
益生菌有望通过调节肠道细菌来预防和治疗胃肠癌. 进一步研究先进的输送方法将增强它们的治疗潜力.
科学领域:
- 胃肠道和瘤学
- 微生物学
- 预防和治疗癌症
背景情况:
- 胃肠道癌症对全球健康构成重大挑战,其中结肠直肠癌 (CRC) 是最常见的.
- 肠道微生物失调与严重的健康问题有关,包括癌症的发展.
- 益生菌的使用正在成为恢复肠道平衡和抗癌的潜在策略.
研究的目的:
- 对益生菌在肠道癌化学预防和治疗中的有效性进行现有体外和体内证据的审查.
- 为了分类益生菌的抗癌机制.
- 讨论肠道癌症治疗中益生菌的未来方向和挑战.
主要方法:
- 在体外和体内研究的系统审查.
- 对抗肠道癌症的益生菌机制的分析.
- 评估当前和未来的益生菌技术.
主要成果:
- 益生菌具有多种抗癌性质:抗增殖,诱导细胞死亡,抗致癌化合物产生,减少化疗毒性,调节肠道微生物群,增强肠道屏障,抗氧化活性,免疫调节和致癌物排毒.
- 证据支持益生菌在预防和治疗肠道癌症中的作用.
- 如封装和基因工程益生菌等先进技术正在开发中.
结论:
- 益生菌是一种有前途的治疗途径,因为它具有多种抗癌作用.
- 通过先进技术优化益生菌的输送对于最大限度地提高疗效和最大限度地减少副作用至关重要.
- 需要进一步的研究,以充分利用益生菌在临床环境中治疗肠道癌症的潜力.
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